a series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. the platelet concentrate was obtained using a two-step centrifugation protocol and adp, arachidonic acid and collagen were used as inducers of platelet a...

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

the use of anticoagulant and antiplatelet agents has become more prevalent during the past decades. these drugs may potentially cause gastrointestinal (gi) bleeding. thus, there is an increasing need for gi endoscopy in patients who take these medications. in patients who take anticoagulant and antiplatelet agents, the appropriate conditions under which endoscopic procedures should be performed...

conclusions this investigation might contribute to delineate the best treatment options for this high risk population. evidence acquisition we reviewed current evidences on the use of antiplatelet therapy in patients with esrd/hd undergoing pci, focusing on the efficacy and safety of specific agents and their indications for detailed clinical settings. results clinical setting in hd patients is...

background: combination antiplatelet therapy is a classic treatment for percutaneous coronary intervention (pci) but this therapy increases gastrointestinal bleeding (gib). this study highlights the incidence of related risk factors of gib and endoscopic findings in patients with gib after pci and combination antiplatelet therapy. materials and methods: a standard check list was used to evaluat...

conclusions regarding the efficacy outcomes of the patients after des implantation, no differences were found between shorter (≤ 6 months) and longer (≥ 12 months) duration of dapt. what is worse is that longer duration (≥ 12 months) was associated with increased risk of bleeding complications. evidence acquisition this study was conducted at the department of cardiology, the first college of c...

Aspirin is an irreversible and non-selective inhibitor of cyclo-oxygenase. It represents the cornerstone of antiplatelet therapy and is used in secondary prevention of cardiovascular disease. Disagreement over the optimal maintenance dosage still exists; in America and Europe the most used doses of aspirin are 81 mg and 100 mg daily, respectively. There is also debate on the formulation and rou...

Background: Clopidogrel is a standout amongst the most ordinarily recommended medications to avoid ischemic occasions taking after coronary disorder or stant position. However, impaired responses the therapy as well as resistance to the therapy have also been reported. Genetic variants play an important role in clopidogrel biotransformation of its active metabolite that may subsequently influen...

background: clopidogrel is one of the most commonly prescribed drugs to prevent ischemic events following coronary syndromes or stent placement. however, impaired responses to therapy as well as resistance are also reported. genetic variants play an important role in clopidogrel biotransformation to its active metabolite that may subsequently influence the clopidogrel antiplatelet effect. the o...