background micrornas are small and non-coding rna molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mrna. mir-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. one of its best known functions is apoptosis that affects on caspase-3 activity. the main aim ...

The present study aimed to investigate the anti-inflammatory effects of Baicalein on human osteoarthritic chondrocytes and its molecular mechanisms, explore related events that may occur. extracted were stimulated with interleukins. After administered different concentrations Baicalein, survival rate was observed. Apoptosis detected by apoptosis assay kit. effect NO production using Griess reag...

Radioresistance is an important cause of cancer treatment failure. Circular RNAs (circRNAs) play crucial roles in development, including the radioresistance. This research aimed to determine function and related mechanism circ_0086720 radioresistance non-small cell lung (NSCLC). The expression circ_0086720, miR-375, Spindlin 1 (SPIN1) was measured using a quantitative real-time polymerase chain...

Spinal cord injury is pathologically characterized by the loss of motor function caused neurons apoptosis. Store-operated calcium entry (SOCE) widely known to dictate apoptosis various cell types. To examine SOCE in spinal and explore role apoptosis, patients with (SCI) SCI mouse models were included. Expression components apoptosis-related proteins examined Western blotting. Calcium imaging wa...

abstractferulago angulata boiss. known in iran as chavir, has some bioactive compounds having antioxidant activity. because of its antioxidant activities, it sounded chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. in this study, the cytotoxic effects and proapoptotic activities of chavir’s leaf and flower extracts ...

To explore the potential mechanism of nobiletin in improving sensitivity breast cancer MDA-MB-231 cells to Pirarubicin. were randomly divided into Control group, Nobiletin Pirarubicin group and co-Pirarubicin group. CCK-8 assay was used detect inhibitory effect on proliferation cells, cell cycle apoptosis detected by flow cytometry. The combined with migration repair ability scratch test. Weste...

Abstract Background Endometrial cancer is an invasive gynecological prevalent in the world. The pathogenesis of endometrial related to multiple levels regulation, referring oestrogen, tumor-suppressor gene (e.g. PTEN ) or microRNAs miR-23a and miR-29b). Metapristone a hormone-related drug, which widely used clinical treatment cancer. However, underlying regulatory mechanism metapristone on stil...

Malignant glioma is the most lethal form of brain cancer, and effective therapeutic modalities remain unavailable to date. We aim investigate whether low-dose curcumin combined with low-intensity ultrasound (LIUS) effectively suppresses growth cells elucidate underlying mechanisms. Glioma were treated LIUS curcumin. Subsequently, effects on determined by CCK-8 assay, EdU flow cytometry analysis...