The modifying effects of garlic (Allium sativum Linn.) on hepatic lipid peroxidation and antioxidant status during 4-nitroquinoline 1-oxide (4NQO)-induced oral carcinogenesis were investigated in male Wistar rats. Enhanced lipid peroxidation in the liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx), glutathione S-transferas...

Aspergillus oryzae was used to enhance the mobilization of antioxidants of soybean matrix along with garlic as a co-substrate by modulating polyphenolic substances during solid-state fermentation. Mobilized polyphenols were used as a green tool for synthesis and stabilization of gold nanoparticles (AuNPs). The radiation-induced AuNPs synthesis is a simple, clean and inexpensive process which in...

The extracts of 17 spices commonly used in Egypt as food condiments were screened for their antimicrobial activities against 7 standard microbial strains (S. aureus, B. subtilis, E. coli, P. aeruginosa, S. typhi, C. albicans and A. niger). Among the tested alcoholic extracts only 3 (clove, thyme and cinnamon) showed broad spectrum antimicrobial activities. Garlic juice too showed broad spectrum...

Background: The production of nitric oxide (NO) is important in the final outcome of leishmaniasis in animal models.Objective: The efficacy of garlic therapy and a combination of garlic and vitamin A were compared with an antimonial drug (glucantime) to assess healing and regulation of NO release in mice infected with Leishmania major.Methods: The mice were subjected to 3´105 promastigotes and ...

Clinical and experimental evidence indicates that garlic ingestion lowers blood cholesterol levels, and treatment of cells in culture with garlic and garlic-derived compounds inhibits cholesterol synthesis. To identify the principal site of inhibition in the cholesterolgenic pathway and the active components of garlic, cultured hepatoma cells were treated with aqueous garlic extract or its chem...

Context: In case of diabetes, persistent and chronic hyperglycaemia may generate free radicals and reactive oxygen species (ROS), which trigger an oxidative stress. Garlic (Allium sativum) is a rich source of bioactive compounds and is used in folk medicine for the treatment of various diseases, including diabetes. Besides, α-tocopherol and magnesium have been shown to possess antioxidative pro...

The present work was carried out to determine the antimicrobial potential of spices and to study whether the crude extracts of spices exhibit any synergistic effect when used in combination with antibiotics. All extracts were most effective against E. coli. The ethanolic extract of turmeric exhibited maximum antimicrobial potential against E. coli (29.3±0.17 mm) followed by garlic (25±0.17 mm) ...