Background: It is believed that the loading value of anticancer drug conjugated to the monoclonal antibody, called drug-to-antibody ratio (DAR), is the main quality feature of antibody-drug conjugates. Methods: In this study, matrix assisted laser desorption/ionization mass spectrometry was used to determine the average molecular weight of trastuzumab and its three conjugated forms. The differe...

in this study, 60 composite samples of dill and onion from two different cultivated areas in khozestan province, iran, were collected and analyzed for the presence and determination of lead and cadmium by flame atomic absorption spectrometry. samples were burned according to aoac at 450 °c, and the residue was dissolved in nitric acid. lead and cadmium contents were determined using calibration...

new advances in mass spectrometry-based proteomics technology are having amajor impact on our understanding of how human spermatozoa acquire their capacity for fertilization. a complete analysis of the proteins found in the human spermatozoa is essential for understanding the events leading up to, and including, fertilization and early embryo development. in this short review, we have collected...

in this study, a rapid, simple and sensitive ion mobility spectrometry (ims) method with corona discharge as ionization source was described for the morphine determination in human urine. morphine was extracted and purified from urine samples using solid phase extraction procedure with c18 column. it can offer the clean extracts which no extra peaks were observed in ims. under operating experim...