Background and Objectives: Apoptosis of eosinophils is of significant value in assessing the airway inflammation in patients with asthma. Our purpose was to investigate the degree of expression of the Bcl-2 protein in sputum eosinophils during acute asthma exacerbation and its relationship with exacerbation severity.    Materials and Methods: The study was carried out in Mostafa Khomeini Ho...

Introduction: Ghrelin is an endogenous peptide that has diverse functions in the body. One of the newly recognized roles of this peptide is its antiapoptotic effect. However, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. This study will examine the effect of ghrelin treatment on Bax-Bcl-2 gene expression in the kidney of chronic hypoxic rats. ...

background: solid ameloblastoma (sab) is an invasive tumor which infiltrates adjacent normal tissues. adenomatoid odontogenic tumor is a noninvasive tumor and never infiltrates surrounding normal tissues. the purpose of this study was to determine the biological behavior of these two epithelial odontogenic neoplasm by detecting ki-67 and bcl-2, which are mitotic and anti apoptotic markers respe...

Purpose: To determine the effect of melatonin in combination with capecitabine on proliferation and induction apoptosis MCF-7 SK-BR-3 breast cancer cell lines.Methods: The MTT assay (3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide) was performed to investigate lines half-maximal concentration (IC50) index. Expression apoptotic markers, Bax, Bcl-2, caspase-3 were measured by polym...

ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. this brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. the aim of this study is investigating the effect of hydroalcoholic extract of  cyperus rotundus l. on the expression of the bcl-x1 an...

Background: B cell CLL/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium’s neuroprotective effect. However, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disorder. The aim of this study was to evaluate whet...