Forkhead-associated (FHA) domains are phosphoprotein-binding modules found in diverse signaling proteins that bind partners phosphorylated on threonine or serine. Kinase-associated protein phosphatase from Arabidopsis employs its FHA domain for negative regulation of receptor-like kinase signaling pathways, which are important in plant development. The solution structure of the free state of ki...

The study of experimental extinction and of the spontaneous recovery of the extinguished memory could cast light on neurobiological mechanisms by which internal representations compete to control behavior. In this work, we use a combination of behavioral and molecular methods to dissect subprocesses of experimental extinction of conditioned taste aversion (CTA). Extinction of CTA becomes appare...

It has been proposed that prostaglandin (PG) D(2) induces physiological sleep in mammals by acting on sleep centers located in the anterior hypothalamus. In fetal sheep, definitive rapid-eye-movement and non-rapid-eye-movement sleep states appear at approximately 125 d gestation (term is approximately 147 d). In adult animals, PGD synthase (PGDS) (functionally and structurally homologous to bet...

Background: The aim of present study was to estimate the levels of some Trace element (Lead, Copper, Cobalt, Chromium, and Cademium) concentrations in Asthenospermia and Normospermia by atomic absorption method, in comparison with control (Fertile), Estimate concentration of (MDA) Malondialdehyde and Total protein concentration in semen specimens.Also relationships between mentioned components ...

Fusion protein technology represents the strategy to achieve rapid, efficient, and cost-effective proteinexpression. Epsilon and Beta toxins are the most potent Clostridial toxins and cause disease in animals.This study describes in silico fusion of Clostridium perfringens types D and B epsilon and beta toxin genesthat was used for cloning in E.coli. The etx and cpb genes were...

Dear Sirs, I would like to reply to Bachmann and Petereit: Beta-trace protein as sensitive marker for liquorrhea. Acta Neurologica Scandinavica 2004; 110: 337–338. A number of recent publications (1–3) deal with the beta-trace protein concentration in nasal secretions as a sensitive marker for cerebrospinal fluid (CSF) rhinorhea and CSF otorhea. In their letter to the editor (4) Bachmann and Pe...

Trace amines such as p-tyramine and beta-phenylethylamine are found endogenously as well as in the diet. Concomitant ingestion of these foodstuffs with monoamine oxidase inhibitors may result in the hypertensive crisis known as the "beer, wine, and cheese effect" attributed to their sympathomimetic action. Trace amines have been shown to act on one of a novel group of mammalian seven transmembr...