ATC-lab(Advanced) is a new, publicly available air traffic control (ATC) simulation package that provides both realism and experimental control. ATC-lab(Advanced) simulations are realistic to the extent that the display features (including aircraft performance) and the manner in which participants interact with the system are similar to those used in an operational environment. Experimental con...

Anaplastic thyroid cancer (ATC) belongs to the most malignant and rapidly progressive human thyroid cancers and its prognosis is very poor. Also, it shows high resistance to cancer treatments, so that effective treatment for ATC has not been found to date, and virtually all patients terminate their life rapidly after diagnosis. Although targeted treatment of genetic alterations has emerged as a...

State Key Laboratory of Bioactive Substance a of Materia Medica, Chinese Academy of Medic Beijing 100050, People's Republic of China. E State Key Laboratory Breeding Base of Da Chinese Materia Medica, China Academy 100700, People's Republic of China † Electronic supplementary information (E IR, and ECD spectra. See DOI: 10.1039/c6 ‡ These authors contributed equally. Cite this: RSC Adv., 2017, ...

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and current treatments are ineffective in increasing patients' survival. Thus, the development of new therapeutic approaches for ATC is needed. We have previously shown that the oncolytic adenovirus dl922-947 induces ATC cell death in vitro and tumor regression in vivo. However, the impact of dl922-947 on the pro...

BACKGROUND The ganglioside GD2 is an attractive target for immunotherapy of neuroectodermal tumors. We tested a unique bispecific antibody anti-CD3 × anti-GD2 (3F8BiAb) for its ability to redirect activated T cells (ATC) to target GD2-positive neuroblastomas. PROCEDURE ATC were generated from normal human peripheral blood mononuclear cells (PBMC) by stimulating the PBMC with OKT3 and expandin...

Introduction Food, besides supplying nutrients, contains a wide variety of bioactive substances, especially food of plant origin. The Swiss sage and physician Paracelsus (1493-1541) regarded plants as being a source of food, medicine and poison. He noted that ‘All things are poisons and nothing is without toxicity. Only the dose prevents anything not to be poisonous’. The term toxicity is gener...

The isolation and partial purification of toxic substances derived from Pfiesteria piscicida Steidinger & Burkholder extracts is described. Four distinct bioassay systems were used to monitor bioactivity of the P. piscicida extracts, including a high throughput cell cytotoxicity assay and a reporter gene assay as well as assays using brine shrimp and fish. Using these bioassays to guide fractio...

Analytical target cascading (ATC) has emerged 12 as an integrated approach and methodology for optimal 13 design of complex hierarchical systems with good conver-14 gence. It facilitates collaborative design problem solving 15 and enables distributed computing to extend both the 16 capability and capacity. ATC is very powerful yet requiring 17 comprehensive understanding and efforts in setting ...

BACKGROUND Weaning from mechanical ventilation is defined as the process of release of ventilatory support and how the evaluation of this phase is conducted in the spontaneous breathing trial (SBT). One of the most used modes of SBT is the continuous positive airway pressure (CPAP), which applies a continuous positive pressure in both inspiration and expiration. However, together with the mecha...