RAPOPORT, STANLEY I., MASAHARU, HORI, AND IGOR KLATZO. Testing of a hypothesis for osmotic opening of the blood-brain barrier. Am. J. Physiol. 223(Z) : 323-331. 1972.-It is hypothesized that some concentrated solutions open the blood-brain barrier to the Evans lllue-albumin complex by shrinking barrier cells and opening up the spaces between them. Four experimental criteria are required if the ...

Metronidazole is a commonly used antibiotic with potent activity against anaerobic bacteria and protozoa. It is believed to cross bloodbrain-barrier and penetrate central nervous system easily. While metronidazole is fairly safe and well tolerated, it can rarely cause serious neurological adverse events, including peripheral neuropathy, cerebellar dysfunction, ototoxicity, seizures, visual impa...

the aim of this study was to investigate the barrier properties of cellulose nanocrystals-pvananocomposites. nanocomposite films with different filler loading levels (3, 6, 9 and 12% by wt) weredeveloped by solvent casting method. the effect of cellulose nanocrystals on the barrier properties ofthe nanocomposites was studied. to this end, moisture absorption, water vapor permeability (wvp),oxyg...

Receptor-mediated drug delivery is a Trojan horse approach for the release of therapeutics into cells, tissues, or organs. By coupling drugs to ligands of cell surface receptors, ligand-drug conjugates can accumulate in specific tissues and can be internalized by cells through the mechanism of receptor-mediated endocytosis.1 Receptors targeted in this way include the low-density lipoprotein (LD...

Interactions between the soma and germline are essential for gametogenesis. In the Drosophila testis, differentiating germ cells are encapsulated by two somatic cells that surround the germline throughout spermatogenesis. chickadee (chic), the fly ortholog of Profilin, mediates soma-germline interactions. Knockdown of Chic in the soma results in sterility and severely disrupted spermatogenesis ...

onstrated no signs of infection and laboratory studies did not reveal a source of infection. Scattered cerebral infarction from arterial air emboli was unlikely because no evidence of ischemia was detected on a diffusion-weighted MRI. The timing of cortical blindness in our patient, shortly after inadvertent arterial entry during attempted PICC line placement, and the focal leptomeningeal enhan...

To apply the nanomaterial as a component in the packaging material structure, in this research, the carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) film were prepared with three levels of nanoclay particles (0.5, 1 and 3%) using solution casting evaporation method. The incorporation of nanoclay on mechanical, water vapor permeability, and oxygen barrier properties of CMC/PVA-based film wa...

The carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) film were prepared by adding three levels of nanoclay particles (0.5, 1 and 3%) using solution casting evaporation method. The incorporation of nanoclay on mechanical, water vapor permeability, and oxygen barrier properties of CMC/PVA-based film was investigated. The best result was obtained through the nanocomposite film contain 3% nano...

During embryogenesis, vascular development is characterized by sequential steps of vasculogenesis, angiogenesis, and in some organs, barriergenesis. In the CNS, the bloodbrain barrier (BBB) is composed of tightly bound endothelial cells (ECs) which regulate the entry of blood-borne molecules and immune cells into the CNS. Perivascular astrocytes are known to regulate BBB permeability and quiesc...

The intestinal epithelium demonstrates differential properties, providing both barrier and transport functions with respect to luminal molecules. Intestinal permeability relates to barrier function and, although it is the ‘permeation’ of molecular markers that is used to measure ‘permeability’, the terms are often confused. Permeability is that property of the intestinal epithelium or of a memb...