Objective(s): Adipose derived stem cells (ADSCs) can be engineered to express bone specific markers. The aim of this study is to evaluate repairing tibia in animal model with differentiated osteoblasts from autologous ADSCs in alginate scaffold. Materials and Methods: In this study, 6 canine’s ADSCs were encapsulated in alginate and differentiated into osteoblasts. Alkaline phosphatase assay (A...

Early assessment of disease response to induction chemotherapy is important in acute myeloid leukemia (AML) in order to plan future therapy and identify chemorefractory disease. Such assessment is customarily performed by examining the bone marrow at around day 14 after initiation of chemotherapy. However, criteria for assessment of residual leukemia in day 14 bone marrow specimens as well as t...

Extraskeletal bone formation can be induced in rodents by implantation of demineralised bone matrix and such implantation has been used to treat bone defects in man, but it is uncertain if induction or merely conduction occurs. We studied bone induction in primates by excising segments of the fibulae of adult squirrel monkeys, defatting and demineralising them before reimplanting them into the ...

objective: this study was conducted with the aim to investigate and compare iranian produced and foreign oxytocin for use in induction of labor. materials and methods: this random clinical trial was conducted on a population of 198 pregnant women with live fetus and cephalic presentation and conditions conducive to induction of labor, monitored by obstetricians and gynecologists. they were rand...

Abstract Aim Bone, joint and soft tissue infections often require long term antibiotic therapy. Reliable IV access is essential for administration monitoring. PICCs provide consistent, long-term access. Aim: improve time to PICC request, insertion, reduce issues with poor in patients requiring antibiotics. Method Standard audit protocol. Data tool was developed tested. collected retrospectively...

BACKGROUND The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor activator of nuclear factor κB ligand (RANKL) blockade on severity of arthritis, bone destruction, and bone formation. METHODS DTHA was induced in C57BL/6 mice. Inflammation, e...

Bone defect, of whatever cause, is clinically challenging to treat. Defects of up to 4.0 cm can be successfully treated with cancellous bone grafting. Large defects require more complex alternatives like, bone transport, vascularized bone grafting, allografts or fibular pro-tibia grafting. There are advantages and disadvantages to these techniques and patient’s cooperation is critical for succe...

Obesity is associated with poorer event-free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL). Persistent minimal residual disease (MRD) in the bone marrow as measured by multidimensional flow cytometry (MDF) is a key early prognostic indicator and is strongly associated with EFS. We therefore hypothesized that obesity during induction would be associated with positive end-of-indu...