Brain-targeted drug delivery is a field of research that seeks to develop new methods for delivering drugs the brain. This done by overcoming blood-brain barrier (BBB), network cells tightly regulate flow substances between blood and Most time lipophilic are easily cross brain but few them less soluble in lipid therefore they don’t barrier. After review we concluded can improve solubility using...

Introduction: Arterial hypertension is one of the causes of stroke, and as one of the vasculotoxic conditions intensifies ischemic stroke complications. The aim of the present study was to analyze the effects of short-term cerebral hypertension on ischemia/reperfusion injury and pathogenesis of ischemic stroke. Methods: The experiments were performed on three groups of rats (N=36) Sham, cont...

Objective: Measurement of blood-brain permeability dysfunction in active and chronic MS lesions with T1-weighted dynamic contrast-enhanced MRI to show variation in inflammatory activity Background: blood-brain-barrier perfusion characterization impaired in MS as some studies have shown recently buta comparison between perfusion parameters in contrast-enhanced and non-enhanced lesions not have ...

Development of an in vitro cell culture system to mimic the blood-brain barrier p. 117 The development of ion regulation at the blood-brain barrier p. 123 An approach to study of transport of trace metals at the blood-brain barrier p. 133 Bidirectional passage of peptides across the blood-brain barrier p. 139 Localization patterns for immunoglobulins and albumins in the brain suggest diverse me...

endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. various micrornas (mirna) have been discovered in different cellular components of the blood bran barrier (bbb). mirnas a...