نتایج جستجو برای: brain uptake
تعداد نتایج: 596037 فیلتر نتایج به سال:
Adenosine uptake sites have been characterized and localized in guinea pig and pointer dog brain by in vitro autoradiography, using as probes 3H-nitrobenzylthioinosine (3H-NBI) and the recently available 3H-dipyridamole (3H-DPR). In guinea pig brain and, to a lesser extent, in pointer dog brain, 3H-DPR was found to label more high-affinity binding sites than 3H-NBI and NBI inhibited 3H-DPR bind...
Recent studies suggest that P-glycoprotein located on the blood-brain barrier restricts the brain uptake of its substrates. We examined the role of P-glycoprotein on the restricted entry of quinidine to the brain. Quinidine is a well known inhibitor of P-glycoprotein, although it is not yet clarified whether quinidine is the substrate for P-glycoprotein. Kinetic analysis of the uptake of quinid...
اخیرا یک سری تحقیقات دامنه داری در زمینه ی تاثیرات پیچیدگی فعلیت محور(task complexity) بر روی تولید کلامی در قالب "صحت"ء "روانی" و "پیچیدگی" گفتار صورت گرفته است. هر چند تاثیرات "پیچیدگی فعلیت محور" برتعامل کلامی و "واکنش فراگیربه بازخورد تصحیح گر"(learner uptake) به ندرت مورد تحقیق قرار گرفته است. به منظور بررسی تاثیرات فعلیت محور بر روی واکنش فراگیر به بازخورد تصحیح گر 38زبان آموز مذکر در سطح...
UNLABELLED The steroid hormone estrogen is important for brain functioning and is thought to be involved in brain diseases, such as Alzheimer disease and depression. The action of estrogen is mediated by estrogen receptors (ERs). To understand the role of estrogens in brain functioning, it is important to study ERs in the brain. The aims of the present study were to determine whether ERs could ...
Accumulation of the amyloid β (Aβ) peptide within the brain is hypothesized to be one of the main causes underlying the pathogenic events that occur in Alzheimer disease (AD). Consequently, identifying pathways by which Aβ is cleared from the brain is crucial for better understanding of the disease pathogenesis and developing novel therapeutics. Cellular uptake and degradation by glial cells is...
glutamate as one of the most important neurotransmitter in the brain has a significant role in control of foodintake. this study examined the central effect of chicago sky blue 6b (csb6 ) as glutamate vesicular uptake inhibitor, on food and water intake in broilers. after icv injection of csb6 cumulative food and water intake were measured in 15,30,60,120 and 180 minutes. csb6 increased food in...
BACKGROUND Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive breast cancer. Drug access to brain metastases and normal brain is key to management of cranial disease. In this study, positron emission tomography (PET) scanning after administration of radiolabelled lapatinib was used to obtain direct evidence of cranial drug access. METHODS Patients with Her-...
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