Neuroleptics are widely prescribed drugs for the treatment of schizophrenia and related psychiatric disorders. Tardive dyskinesia (TD) is a late complication of prolonged neuroleptic treatment. Despite much research, the pathogenesis of TD remains elusive. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. Tardive dyskinesia has b...

Abstract:Purpose:This study was designed determine the efficacy of bupropion versus placebo in subjects with negative symptoms of schizophrenia.Methods:A convenience sample of 40 patients of both genders aged 18-60 years who were living in psychiatric care centers were randomly treated with bupropion (started with 75 mg twice a day; increased to 100 mg thrice daily) or placebo. The diagnosis of...

The case is reported of a patient who had taken a deliberate overdose of sustained release bupropion. The patient suffered from prolonged symptoms including seizures before fully recovering. The prescription of bupropion is encouraged as an aid to smoking cessation and it is probable that bupropion overdose will become more common. Emergency departments need to be aware that patients taking an ...

Bupropion, an efficacious antidepressant and smoking cessation agent, inhibits dopamine and norepinephrine transporters (DAT and NET, respectively). Recently, bupropion has been reported to noncompetitively inhibit alpha3beta2, alpha3beta4, and alpha4beta2 nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes or established cell lines. The present study evaluated bupropion-ind...

Objective: Traditionally, studies on the non-medical use of pharmaceutical products have focused on controlled substances; e.g., opiates/opioids; and benzodiazepines. Although both bupropion and venlafaxine have been reported as being misused, only anecdotal reports have been made available so far. Hence, the European Monitoring Agency (EMA) Adverse Drug Reactions (ADRs), misuse/abuse/dependenc...

Bupropion hydrochloride ((±)-2-tert-butylamino)-3 -chloropropiophenone · HCl) is a nonselective inhibitor of the dopamine transporter (DAT) and the norepinephrine transporter (NET) and is also an antagonist at neuronal nicotinic acetylcholine receptors (nAChRs). In animal models used commonly to screen for antidepressant activity, bupropion shows a positive response. Also using animal models, b...

BACKGROUND Bupropion hydrochloride is used frequently in the treatment of depression and in smoking cessation therapy. METHODS We report a case of bupropion hydrochloride induced serum sickness-like reaction. RESULTS There was complete resolution of symptoms on discontinuing bupropion and instituting therapy with prednisone and antihistamines. CONCLUSION This case is seemingly the first r...

Bupropion is widely used for treating bipolar disorder (BD), and especially those with depressive mood, based on its good treatment effect, safety profile, and lower risk of phase shifting. However, increasing evidence indicates that the safety of bupropion in BD patients may not be as good as previously thought. The aim of this study was to summarize data on the treatment effect and safety pro...

BACKGROUND Bupropion HCl is a widely used antidepressant that is known to cause seizures in a dose-dependent manner. Many patients taking antidepressants will consume alcohol, even when advised not to. Previous studies have not shown any interactions between bupropion HCl and alcohol. However, there have been no previous studies examining possible changes in seizure threshold induced by a combi...

Bupropion is an antidepressant with excellent tolerability and fe to side f!ffects or drug interactions. These characteristics suite it ioellfo r use both in the elderly and in the medically ill. Huwever, early reports ofseirures with bupropion therapy in patients with bulimia limited its use. The pharmacology, tdJicacy, toxicity, and side dftct profile qfboth the immediate release (IR) and the...