A new and selective breast cancer-targeting prodrug system is described based on the Staudinger ligation bioorthogonal reaction.

Abstract Background Nanoparticulate drug delivery systems have attracted significant attention in the field of cancer nanotechnology. This study determines the effect of folate-based Fe2O3 nanoparticles. This study aimed to decorate nanoparticles with folate (FA), a molecular ligand for ‘active’ targeting of cancerous cells and the application of modified-nanoparticles in cancer treatment. ...

A 65 year old male with metastatic colorectal cancer (mCRC) in the liver was referred for selective internal radionuclide therapy (SIRT) following a history of extensive systemic chemotherapy. 90Y PET imaging was performed immediately after treatment and used to confirm lesion targeting and measure individual lesion absorbed doses. Lesion dosimetry was highly predictive of eventual response in ...

The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories  including nucleosome remodeling and RNA mediated targeting have been strongly investigated  recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the  tumorogenesis and cancer progression. Moreover...

Damage of the normal tissue is a serious concenrn in cancer treatment. Hyperthermia by laserhas been considered as a safe cancer treatments methods with lower harmful effects on normaltissues. Using nanoparticles in cancer treatment has improved laser therapy, which is based ona selective cell targeting method to localize cell damages. Metallic nanoparticles such as gold,silver, and copper have...

When a cell’s DNA is damaged, the injured cells react by changing from normal to malignant cells, rather than dying or repairing the damage. Metastatic cancer is the deadliest kind of cancer since it refers to cancer that has spread to other parts of the patient’s body. The need for cancer detection techniques that are rapid, non-invasive, and accurate is growing. Cancer diagnosis, monitoring, ...

Introduction: Photothermal therapy (PTT) is a nanotechnology-assisted cancer hyperthermia approach in which the interaction between laser light and plasmonic nanoparticles generates a localized heating for thermoablation of the tumor. Recent efforts in the area of PTT follow two important aims: (i) exploitation of targeting strategies for preferential accumulation of plasmonic ...

COPYRIGHT © 2007 NEW MEDICINE INC. UNAUTHORIZED PHOTOCOPYING, DISTRIBUTION OR ELECTRONIC STORAGE IS PROHIBITED BY LAW. THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY IN CANCER PART II — TARGET CANCER INDICATIONS AND TARGETING APPROACHES ERBB RECEPTORS ASSOCIATION BY CANCER INDICATION 1958 EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) 1959 Colorectal Cancer 1959 Head and Neck Cancer 1960 Lung Can...

Context: Somatic mutation theory has been considered as a potential cause for cancer. However, major inconsistencies with the gene have necessitated serious reconsideration of this assumption. According to these inconsistencies, cancer may be metabolic disorder. mitochondrial theory, substrate-level phosphorylation suggested superior oxidative in cells. Cancer therapies such ketogenic diets (KD...