نتایج جستجو برای: caspase activity

تعداد نتایج: 1158507  

Journal: :iranian journal of pharmaceutical research 0
karim ebrahim department of toxicology, school of pharmacy, shahid beheshti university of medical sciences hossein vatanpour department of toxicology, school of pharmacy, shahid beheshti university of medical sciences abbas zare razi vaccine and serum research institute farashad h.shirazi pharmaceutical sciences research center, shahid beheshti university of medical sciences maryam nakhjavani department of toxicology, school of pharmacy, shahid beheshti university of medical sciences

abstract cancer is the leading cause of death worldwide. current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new anticancer agents especially from the screening of natural compounds. present study investigated cytotoxic effects and mode of cell death induced by the caspian cobra venom in some human cancer cell lines. cytotoxic effects of snake venom toxin...

Journal: :physiology and pharmacology 0
آزاده عبدی azadeh abdi فاطمه محققی fatemeh mohagheghi سید همایون صدرایی homayoon sadraei لیلا درگاهی leila dargahi لیلا خلج leila khalaj ابوالحسن احمدیانی abolhassan ahmadiani

introduction: evidence suggests that neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. the beneficial or detrimental role of apoptosis in neuroinflammation is unclear. elucidating this question may be helpful in management of neurodegenerative diseases. since tnf-α is able to induce apoptosis as well as increased viability of the cells by activation of ...

      ICD-85 (venom derived peptides) has anti-proliferative effect and anti-angiogenesis activity on cancer cells. This study was performed to test the effect of ICD-85, on Human breast adenocarcinoma (MCF-7) and normal Human Dermal Fibroblasts (HDF) cell lines. In this experimental study, Mitochondrial activity, Neutral red uptake, Lactate dehydrogenase (cell necrosis), and cell morphology we...

Journal: :Iranian journal of neurosurgery 2023

Background and Aim: Smoking has been extensively investigated in oncology, controversial associations with brain tumor incidence have reported. Caspase-3 matrix metalloproteinases (MMPs) belong to an important cascade vasculogenesis. We aim study the smoking impact on these signaling molecules nontumoral rat tissue. Methods Materials/Patients: A total of 60 Wistar rats were divided into two gro...

Journal: :research in pharmaceutical sciences 0
fereshteh delghandi moghadam javad baharara saeedeh zafar balanezhad mohsen jalali elaheh amini

sea cucumbers saponins are triterpenoid glycosides which exert beneficial biomedical effects. this study was performed to assess the effect of saponin extracted from sea cucumber holothuria leucospilota            ( h. leucospilota ) on maturation of mice oocytes and granulosa cells. the germinal vesicles oocytes were collected from 6–8 weeks old naval medical research institute (nmri) mice ova...

2017
Jaewon Lim Hyun-Kyung Kim Sung Hoon Kim Ki-Jong Rhee Yoon Suk Kim

Triglyceride (TG) accumulation causes macrophage cell death, which affects the development of atherosclerosis. Here, we examined whether caspase-2 is implicated in TG-induced macrophage cell death. We found that caspase-2 activity is increased in TG-treated THP-1 macrophages, and that inhibition of caspase-2 activity drastically inhibits TG-induced cell death. We previously reported that TG-ind...

جیواد, فرشته, حسینی, وحید, حقی امین جان, حامد, شکرزاده, محمد, عابدیان کناری, سعید, علیزاده, احد, فرزاد, فرامرز, قاسمی, مریم,

Background and purpose: Gastric cancer is one of the most prevalent cancers with a low-five year survival rate. Some factors such as molecular pathway are associated with the development of disease and metastasis is the most important factor for death. Caspase 9 is initiator CASP of internal apoptosis pathway and have important role in cancer development. Polymorphism of CASP 9 gene promoter co...

      ICD-85 (venom derived peptides) has anti-proliferative effect and anti-angiogenesis activity on cancer cells. This study was performed to test the effect of ICD-85, on Human breast adenocarcinoma (MCF-7) and normal Human Dermal Fibroblasts (HDF) cell lines. In this experimental study, Mitochondrial activity, Neutral red uptake, Lactate dehydrogenase (cell necrosis), and cell morphology we...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2007
Kathleen A Stringer Meghan Tobias Heidi C O'Neill Christopher C Franklin

Neutrophils are the primary inflammatory cell in smokers' lungs, but little is known about the ability of cigarette smoke to modulate neutrophil function. Neutrophils undergo caspase-3-dependent spontaneous, as well as phagocytosis-induced, apoptosis. This study investigated the ability of cigarette smoke extract (CSE) to alter neutrophil caspase-3 activity, apoptosis, and phagocytosis. CSE tre...

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