Unanesthetized macaque monkeys were subjected to middle cerebral artery (MCA) occlusion. Local cerebral blood flow (ICBF) was measured with a hydrogen clearance technique. Mean arterial blood pressure, arterial blood gases, and intracranial pressure were monitored serially. Two weeks after ischemic insult, a neuropathologic examination documented cerebral infarction and its relation to CBF reco...

BACKGROUND AND PURPOSE In patients who have major cerebral arterial occlusive disease with low perfusion, a decrease in cerebral metabolism may be reflected by a reduction in contralateral cerebellar blood flow (crossed cerebellar hypoperfusion). This study was done to investigate whether comparison of the extent of cerebral blood flow asymmetry and crossed cerebellar hypoperfusion could be use...

We assessed the cerebral blood flow velocity response to head-up tilt test in patients with typical neurocardiogenic syncope compared with patients showing postural tachycardia. Fifty patients (21 men) with history of orthostatic intolerance, younger than 50 years (mean 27 +/- 10), participated in the study. Transcranial Doppler sonography of the middle cerebral artery, heart rate and brachial ...

Rapid vascular resistance adjustments in the brain and in the circle of Willis have been continuously measured and enhanced by signal averaging methods. Naftidrofuryl, a drug chemically similar to local anesthetics and to beta adrenergic blocking agents, increases local CBF by reducing resistance in brain and in extracerebral supply arteries. It has also been reported to affect brain metabolism...

CEREBRAL BLOOD FLOW Edited by M. Brock, C. Fieschi, D. H. Ingvar, N. A. Lassen, and K. Schurmann. (Pp. xx + 291; 113 figures; DM 58). Springer: Berlin. 1970. Measurement of the cerebral blood flow using isotope techniques is a field in which European centres have held the lead since their introduction by Lassen and Ingvar and by Harper exactly 10 years ago. Conferences at which the initiated ar...

The steal phenomenon due to a vasodilator was investigated in 6 cats in which cerebral ischemia had been produced by left middle cerebral artery (MCA) occlusion. The photoelectric method was employed for continuous recording of the cerebral blood volume together with frequent determinations of the cerebral blood flow (CBF) through the ischemic cerebral tissue at the following four stages: befor...

V0 is the vascular distribution volume for the tracer in the tissue. In bolus type experiments such as H2O PET, this term is significant, whereas for inhalation of Xenon, the vascular term is not generally included, and Vo = 0. To measure CBF, the free parameters in Eq 1 are varied to obtain an optimal fit of the expression to regional uptake curves, using non-linear, least squared regression a...

Alterations in cerebral blood flow produced by controlled episodes of hypotension were studied in 12 juvenile monkeys using a thermocouple techique. The qualitative changes observed agreed closely with those obtained from an earlier study employing [14C]antipyrine autoradiographic methods. The present study extends the validity of the earlier antipyrine investigations by means of the continuous...