background & objectives: ischemic stroke is the third leading cause of death and disability in most of the human societies. there is no effective treatment due to complexity of the pathophysiological mechanisms. today, more researches are designed to introduce involving factors and new treatment strategies in brain ischemia. the objective of this study is to introduce an experimental model of t...

BACKGROUND AND PURPOSE To assess the usefulness of transcranial Doppler sonography, we investigated the rate of blood flow signal recording failure in the middle cerebral artery in Japanese subjects. Furthermore, we studied the effect of increased emitted power on the rate of successful recording in some of the patients in whom recording failure had been detected at the standard transducer powe...

background: the mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood.   objective: to investigate the role of nitric oxide (no) and atp-sensitive potassium (k atp ) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels.   methods: the change in cerebral blood flow was measured by a laser doppler flowmeter in...

the mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. to examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit. cerebral blood flow was measured by laser doppler flow-meter in 18 nzw rabbits anesthetized with sodium pentobarbital.  tetrodetoxin...

adenosine has many of the characteristics of a regulator of cerebral blood flow and adenosine receptors change in morphine dependency. in this study the changes in adenosine receptors' responsiveness of pial vessels in the hind limb area of the sensory cortex were evaluated in morphine dependent rats (mdr) using the laser doppler flowmetry technique. adult male sprague dawley rats (250-350...

Background: The mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood. Objective: To investigate the role of nitric oxide (NO) and ATP-sensitive potassium (KATP) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels. Methods: The change in cerebral blood flow was measured by a laser Doppler flowmeter in 18 Ne...

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background: nitric oxide synthase (nos) activity is increased during hypertension and cerebral ischemia. nos inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (bbb) disruption and cerebral edema formation during stroke in acute hypertension. here, we investigated the role of nos inhibition in progression of edema formation and bbb d...

The mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. To examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit.Cerebral blood flow was measured by laser Doppler flow-meter in 18 NZW rabbits anesthetized with sodium pentobarbital.  Tetrodetoxin ...

alzheimer's disease (ad) is considered as the greatest thread to adults aged 65 and older. it stands as the most common cause of dementia, the prevalence of which is around 24 million worldwide. ad is a progressive and degenerative disorder that combats the neurons, leading to impairment of different cognitive functions. ad is characterized by an accumulation of two factors normally presen...