نتایج جستجو برای: chr m 1
تعداد نتایج: 3058110 فیلتر نتایج به سال:
Normal hearing in mammals depends on sound amplification by outer hair cells (OHCs) presumably by their somatic motility and force production. However, the role of OHC force production in cochlear amplification and frequency tuning are not yet fully understood. Currently, available OHC manipulation techniques for physiological or clinical studies are limited by their invasive nature, lack of pr...
Abstract We obtain a polynomial upper bound on the mixing time $T_{CHR}(\epsilon)$ of coordinate Hit-and-Run (CHR) random walk an $n-$ dimensional convex body, where is number steps needed to reach within $\epsilon$ uniform distribution with respect total variation distance, starting from warm start (i.e., which has density body that bounded above by constant). Our in n , R and $\frac{1}{\epsil...
Constraint Handling Rules (CHR) is a high-level rule-based programming language. In [11], a model of computation based on the operational semantics of CHR is introduced, called the CHR machine. The CHR machine was used to prove a complexity-wise completeness result for the CHR language and its implementations. In this paper, we investigate three generalizations of CHR machines: CHR machines wit...
To identify genetic determinants of lipoprotein levels, we are performing quantitative trait locus (QTL) analysis on a series of mouse intercrosses in a "daisy chain" experimental design, to increase the power of detecting QTL and to identify common variants that should segregate in multiple intercrosses. In this study, we intercrossed strains CAST/Ei and 129S1/SvImJ, determined HDL, total, and...
This is a summary of the Ph.D. thesis of Tom Schrijvers [4]. Constraint Handling Rules (CHR) [3] is a rule-based language commonly embedded in a host language. It combines elements of Constraint Logic Programming and term rewriting. Several implementations of CHR exist: in Prolog, Haskell, Java and HAL. Typical applications of CHR are in the area of constraint solving, but currently CHR is also...
Mutations in the promoter of telomerase reverse transcriptase (TERT) gene have been described as most common hot-spot mutations different solid tumors. High frequencies TERT reported to occur tumors arising tissues with low rates self-renewal. For cutaneous vascular tumors, prevalence has not yet investigated larger mixed cohorts. With targeted next-generation sequencing (NGS), we screened for ...
The tumor suppressor p53 plays an important role in cell cycle arrest by downregulating transcription. Many genes repressed by p53 code for proteins with functions in G₂/M. A large portion of these genes is controlled by cell cycle-dependent elements (CDE) and cell cycle genes homology regions (CHR) in their promoters. Cyclin B2 is an example of such a gene, with a function at the transition fr...
Under the guidance of the Chromosome-centric Human Proteome Project (C-HPP), (1, 2) we conducted a systematic survey of the expression status of genes located at human chromosome 20 (Chr.20) in three cancer tissues, gastric, colon, and liver carcinoma, and their representative cell lines. We have globally profiled proteomes in these samples with combined technology of LC-MS/MS and acquired the...
The receptor gp130 is utilized by cytokines including interleukin 6, leukemia inhibitory factor, oncostatin M, cilary neurotrophic factor and cardiotrophin. It is essential for myocardial development and haematopoiesis during embryogenesis, and its role as a shared signal transducer among different cytokines explains their overlapping biological functions. Although gp130 contains a cytokine-bin...
Previously, linkage analysis in several experimental crosses between hypertensive rat strains and their contrasting reference strains have identified a major quantitative trait locus (QTL) for blood pressure on rat chromosome 1 (Chr 1) spanning the Sa gene locus. In this study, we report the further dissection of this Chr 1 blood pressure QTL with congenic substitution mapping. To address wheth...
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