Introduction: The diagnosis of chronic lymphocytic leukemia/ small lymphoma (CLL/SLL), which also includes atypical forms, can be very difficult. aim this study is to compare immunohistochemical (IHC) and flow cytometric (FC) immunophenotyping methods in the CLL/SLL, most common mature B-cell leukemia/lymphoma adults, bone marrow biopsy. In these two methods, it determine minimum panels that di...

Chronic lymphocytic leukemia/small lymphoma (CLL/SLL) is characterized by the accumulation of abnormal lymphocytes in blood, bone marrow, and lymphoid tissues, leading to a weakened immune system an increased risk infections for patients. The NCCN Guidelines CLL/SLL underscore need comprehensive evaluation multiple factors determine most appropriate treatment approach each patient. For frontlin...

Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are the most common leukemias of the elderly (>43 year). However, the sequential occurrence of CML followed by CLL in the same patient is extremely rare. In our report, a 52-year-old female was diagnosed with CLL (type of bone marrow (BM) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months ...

APRIL (a proliferation-inducing ligand) and BLyS (B lymphocyte stimulator) expression have been reported in chronic lymphocytic leukemia (CLL) cells. We examined APRIL and BLyS serum levels in CLL patients and evaluated the prognostic significance of APRIL expression on survival.

Human lymphocyte extracts analyzed by high-performance liquid chromatography reveal a major UV-absorbing peak that was shown to be ascorbic acid by spectral, chemical, and enzymatic criteria. Because this peak appeared very prominent in the elution profile of chronic lymphocytic leukemia (CLL) lymphocyte extracts, we measured the ascorbic acid content in lymphocytes from the blood of normal sub...

Comorbidities including leukemia are risk factors in coronavirus disease 2019 (COVID-19) patients for high morbidity and mortality. The severity of the is usually correlated with lymphopenia. On other hand, we came across a case marked absolute lymphocytosis COVID-19 patient, which further escalated five-fold during his hospital stay. Subsequently, diagnosis chronic lymphocytic (CLL) was made f...

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common form of leukemia affecting adults in Europe and North America. Large B-cell lymphoma known as Richter's syndrome (RS) may develop approximately in 3-15 % patients. Furthermore, other hematological malignancies may also occur as RS variants, among them-Hodgkin lymphoma (HL). CLL/SLL transformation into HL...

Infectious complications are an important cause of hospitalization in patients diagnosed with chronic lymphocytic leukemia. The pathogenesis of infection is complex, involving both disease-induced and treatment-related immune depression. During the last decade, the management of chronic lymphocytic leukemia (CLL) has been redefined by the approval of monoclonal antibody-based treatment, which r...

Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL patient has any symptoms suggesting a possible GI manifestation of the haemat...