The case is presented of a 5 year old boy who attended after an inversion injury. He had persistent pain despite treatment and was subsequently diagnosed with acute myelogenous leukaemia. It is well recognised that acute leukaemia commonly presents as non-traumatic limb pain. This case highlights the need to consider acute leukaemia in the differential diagnosis of any persisting bone or joint ...

Introduction In Nature, the vast majority of polypeptides are synthesized through translation of the messenger RNA (mRNA) by the joint action of the ribosome and the transfer RNA (tRNA). The mRNA is a transcribed copy of the gene that carries genetic information in the form of series of three-nucleotide sequences referred as ‘codon’. Each codon corresponds to a specific amino acid or a terminat...

The leucocytes of the blood of normal individuals and of patients showing a marked polymorphonuclear leucocytosis contain enzymes capable of digesting coagulated blood serum in neutral, alkaline or acid solutions. The cells in pus that is composed principally of polymorphonuclear leucocytes and the leucocytes of the circulating blood in myelogeneous leukaemia contain similar proteolytic enzymes...

1 Bero LA, Grilli R, Grimshaw JM, Harvey E, Oxman AD, Thomson MA. Closing the gap between research and practice: an overview of systematic reviews of interventions to promote the implementation of research findings. The Cochrane Effective Practice and Organisation of Care Review Group. BMJ 1998;317:465-8. 2 Grol R. Improving the quality of medical care. Building bridges among professional pride...

Background: Bone marrow examination is a safe invasive procedure and can provide sufficient explanation for unexplained cytopenias, leukaemia other haematological disorders including metastases to the by detailed morphological description of elements. Objective: To see importance bone diagnosis disorders. Materials Methods: It was descriptive cross-sectional study comprising 196 patients who un...