Manatees are a vulnerable, charismatic sentinel species from the evolutionarily divergent Afrotheria. Manatee health and resistance to infectious disease is of great concern to conservation groups, but little is known about their immune system. To develop manatee-specific tools for monitoring health, we first must have a general knowledge of how the immunoglobulin heavy (IgH) chain locus is org...

Last night’s Student Life Council meeting resulted in a direct confrontation between students and the faculty-administration members o f the council over the issue of the Board of Trustees’ response to the SLC report on Hall Life. The split began with a motion by Student Body President Dave Krashna to reject the Trustees report, and by the meeting’s close had come close to being reduced to a ch...

NAIP CIIA HET-E and TP1 (NACHT) family proteins are involved in sensing intracellular pathogens or pathogen-derived molecules, triggering host defense responses resulting in caspase-mediated processing of proinflammatory cytokines and NF-kappaB activation. Caspase-associated recruitment domain, leucine-rich repeat, and NACHT-containing protein (CLAN), also known as ICE protease-activating facto...

Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling pathways, often in creative ways. CE clan proteases, specific hydrolases for ubiquitin-like modifications (SUMO and NEDD8) in eukaryotes, reportedly serve as bacterial effector proteins with deSUMOylase, deubiquitinase, or, even, acetyltransferase activities. Here, we characterize bacterial CE protease activitie...

Differences in the social systems and behaviour of two potentially important hosts of rabies, the African wild dog and the spotted hyaena, may lead to differences in the epizootiology of the disease in the two species. Wild dogs are highly social animals in which pack members are in constant physical contact with each other, but in which inter-pack interactions are rare. Spotted hyaenas are mor...

Sperm whales (Physeter macrocephalus) are unusual in that there is good evidence for sympatric populations with distinct culturally determined behaviour, including potential acoustic markers of the population division. In the Pacific, socially segregated, vocal clans with distinct dialects coexist; by contrast, geographical variation in vocal repertoire in the Atlantic has been attributed to dr...

Human paracaspase has been predicted to be a member of the protein structural fold that encompasses protease clan CD. To determine whether paracaspase has catalytic activity we have expressed the region corresponding to the catalytic domain and used protease activity-based chemical probes to profile the putative active site. A leucine-based acyloxymethyl ketone probe that covalently labels cyst...

Although IS literature is quite rich on analyzing control modes in interorganizational relationships, there exists quite sparse empirical work on the effects of control modes on the relationship between a platform vendor and thirdparty developers in software-based platform ecosystems. Drawing on IS control literature and trust theory, we conducted an online survey with 125 game developers of th...