Colchicine overdose is rare but potentially a life threatening toxicological emergency. The severity of colchicine toxicity does not necessarily correlate with the amount of colchicine ingested and may depend on co-ingested agents. Some patients require intensive care. We report two cases of colchicine overdose with unusual presentations requiring intensive care. Case 1: A 37-year-old man took ...

interference with microtubule polymerization results in cell cycle arrest leading to cell death. colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. a set of 3',4'-bis (substituted phenyl)-4'h-spiro[indene-2,5'-isoxazol]-1(3h)-one derivatives with known antiproliferative activities were evaluated for their t...

Colchicine is a well-known lipophilic drug acting on microtubule growth. It can be used to prevent attacks of fever, arthritis and peritonitis in patients with familial Mediterranean fever (FMF). No human cytogenetic or teratogenic effects have been attributed to colchicine; in particular, the increased incidence of Down’s syndrome initially reported appears to be coincidental and it is now con...

Background and Objectives: Study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. In this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (CA1) was examined by the studying the hippocampal tissue. Materials and Methods: Injections of colchicine (1-75 μg/rat, intra- hippocampal CA1) were performed in cannulated male Wistar rat...

Wheat meiocytes contain intranuclear bundles of microfibres at stages from pre-meiotic mitosis until zygotene. This includes early pre-meiotic interphase, the stage when colchicine induces univalents at subsequent metaphase I. This paper reports the effect of colchicine on the structure and distribution of such fibrillar material. Many normal-looking bundles of intranuclear fibrillar material f...

To quantify the colchicine (alkaloid) present in Gloriosa superba by High Performance Liquid Chromatography (HPLC) method. Gloriosa superba species are known for their content of colchicine, a valuable alkaloid in the seeds and tubers (corms). HPLC analysis was carried out to confirm the presence of colchicine in Gloriosa superba. Treatment of gibberellic acid and Psedomonas aerugenosa improved...

Introduction Patients with familial Mediterranean fever (FMF) routinely take large daily doses of colchicine to both prevent and abort acute attacks (1,2) and to reduce the risk of developing amyloidosis (3). Unfortunately, colchicine can also cause a number of toxic side effects, including neuromyopathy. Almost all cases of colchicine neuromyopathy previously described have been associated wit...

Colchicine has been discovered to inhibit many inflammatory processes such as gout, familial Mediterranean fever, pericarditis and Behcet disease. Other than these beneficial anti-inflammatory effects, colchicine blocks microtubule-assisted axonal transport, which results in the selective loss of dentate granule cells of the hippocampus. The mechanism of the colchicine-induced dentate granule c...

Since colchicine-sensitive microtubules regulate the expression and topography of surface glycoproteins on a variety of cells, we sought evidence that colchicine interferes with neutrophil-endothelial interactions by altering the number and/or distribution of selectins on endothelial cells and neutrophils. Extremely low, prophylactic, concentrations of colchicine (IC5. = 3 nM) eliminated the E-...