Controlled drug through diffusion and activation-based drug delivery devices have become commercially feasible due to converging technologies and regulatory accommodation. Combination products constructed using implantable technology offer revolutionary opportunities to address unmet medical needs related to dosing. These products have the potential to completely control drug release, meeting r...

conclusions the results indicated that sod-loaded in sln was delivered into deep burned skin layer and induced high enzyme activity through the skin. low particle size, application of lecithin as surfactant and low crystallinity index (ci) percentage were important factors for increasing sod penetration through the burned rat skin. percentage of activity by sln dispersions through rat skin was ...

objective(s): nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. temperature and ph-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or ph. the objective of this work is to prepare and characterize composite membrane using responsive nanoparticles into a polymer...

microspheres formulated from poly (d,l-lactic-co-glycolide) (plga), a biodegradable polymer, have been extensively evaluated as a drug delivery system. in this study, the preparation, characterization and drug release properties of the plga microspheres were evaluated. simvastatin (sim)-loaded plga microspheres were prepared by oil-in-water emulsion/solvent evaporation method. the microspheres ...

Holey photonic crystal (PC) microcapsules are generated through a combined technique of microfluidic- and controlled-photopolymerization. This versatile route allows the fine tuning of shell structure (from well-ordered nanoporous to single-hole structures with tailored hole size) by etching or by varying UV light intensity, and endowing the PC microcapsules with multifunctional properties.

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

PURPOSE Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular ...

      The objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (DDS) for Metoprolol tartarate (MT) as tablet and capsule. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal del...

Nowadays the application of nanotechnology in different biomedical fields such as drug delivery is increasing due to its unique advantages. With this in mind, it is widely believed that nanogels as the nanometer-sized networked polymeric particles have a considerable impact on drug delivery systems as biocompatible nanocarriers due to their unique characteristics such as high loading capacity, ...