BACKGROUND Emerging antenatal interventions and care delivery to the fetus require diagnostic support, including laboratory technologies, appropriate methodologies, establishment of special algorithms, and interpretative guidelines for clinical decision-making. CONTENT Fetal diagnostic and therapeutic interventions vary in invasiveness and are associated with a spectrum of risks and benefits....

Small supernumerary marker chromosomes (sSMC) are still a major problem in clinical cytogenetics as they cannot be identified or characterized unambiguously by conventional cytogenetics alone. On the other hand, and perhaps more importantly in prenatal settings, there is a challenging situation for counseling how to predict the risk for an abnormal phenotype, especially in cases with a de novo ...

Fetal trisomy 9 is a rare chromosomal abnormality, which was difficult to diagnose in the prenatal period. Here is reported a case of mosaic trisomy 9 fetus, prenatally detected by ultrasound examinations in the second trimester and confirmed by karyotyping from amniocentesis and cordocentesis. The fetus presented multiple malformations, especially facial deformity, polycystic kidney disease an...

AIM 1) We have presented our experiment conducted to detect anti-K antibodies from the Kell-system in pregnant women and their connection with potential destruction of foetal red cells, which may result in haemolytic disease of the foetus and the newborn (HDFN). 2) We have also indicated serological and molecular methods important for a proper diagnosis. MATERIAL AND METHODS 27 women with ant...

1 Nicolaides KH, Soothill PW, Clewell WH, Rodeck CH, Mibashan R, Campbell S. Fetal haemoglogin measurement in the assessment of red cell isoimmunisation. Lancet 1988;i: 1073-5. 2 Rodeck CH, Nicolaides KH, Warsof SL, Fysh WJ, Gamsu HR, Kemp JR. The management of severe rhesus isoimmunisation by fetoscopic intravascular transfusions. Amj Obstet Gynecol 1984;150:769-74. 3 Nicolaides KH, Soothill P...

Purple urine bag syndrome (PUBS) is a rare condition in which purple discoloration of the collecting bag and its associated tubing occurs. It is considered a benign condition. PUBS is usually associated with urinary tract infection occurring in elderly bedridden women, with chronic urinary catheterization. This syndrome is usually reported to occur in alkaline urine, but here we describe a rare...

BACKGROUND Traditional survey methods may cause refusals to respond or untruthful replies when encounter the sensitive questions. The Randomized Response Technique (RRT) is designed to decrease social desirability bias and obtain reliable estimates. This study aimed to apply these new methods on the sensitive questions survey. METHODS Simmons model was applied in the survey of issues relevant...

Small supernumerary marker chromosomes (sSMC) are still a major problem in clinical cytogenetics as they cannot be identified or characterized unambiguously by conventional cytogenetics alone. On the other hand, and perhaps more importantly in prenatal settings, there is a challenging situation for counseling how to predict the risk for an abnormal phenotype, especially in cases with a de novo ...