In complex task domains, such as games, students may exceed their teachers. Such tasks afford diverse means to tradeoff one type of performance for another, combining task elements in novel ways to yield method variations and strategy discoveries that, if mastered, might produce large or small leaps in performance. For the researcher interested in the development of extreme expertise in the wil...

The growing need for a trustworthy Future Internet demands evolutionary approaches unfettered by legacy constrains and concepts. The networking community is calling for new network architectural proposals that address the deficiencies identified in present network realizations, acknowledge the need for a trustworthy IT infrastructure, and satisfy the society's emerging and future requirements. ...

Carbon monoxide releasing molecules (CORMs) have been recently developed for research and pharmacological purposes. A considerable amount of studies demonstrated a wide spectrum of biological activities for lipophilic CORM-2 (tricarbonyldichlororuthenium (II) dimer). It is generally accepted that the liberated gas provides the specific activities to CORMs, with a little attention paid to any po...

in order to investigate the effect of high density and depth of planting on agronomic characteristic of saffron, a field experiment was conducted as a complete randomized block design with three replications in faculty of agriculture, ferdowsi university of mashhad, iran during two growing seasons of 2008-2009 and 2009-2010. treatments were six levels of high densities (8, 11, 13, 16, 19 and 21...

seventeen iranian shallot genotypes from ashtian, arak, boroujerd, dashtearjan, doshmanziari, divandareh, khomein, khansar, sepidan, siakhdarengoon, sahne, kangavar, koohrang, koohmaresorkhi, nahavand, harsin and yasouj areas were evaluated for their morphological traits. corms were collected from the mentioned regions and planted based on a complete block design. quantitative and qualitative t...

OBJECTIVES Previous work has shown that the CO-releasing molecule CORM-2 protects against cartilage degradation. The aim of this study was to examine whether CORM-2 can control the production of inflammatory mediators in osteoarthritic chondrocytes and determine the mechanisms involved. METHODS Primary cultures of chondrocytes from OA patients were stimulated with IL-1beta. The production of ...

Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, is an important signaling mediator in mammalian cells. Here we show that precise delivery of CO to isolated heart mitochondria using a water-soluble CO-releasing molecule (CORM-3) uncouples respiration. Addition of low-micromolar concentrations of CORM-3 (1-20 μM), but not an inactive compound that does ...

AIMS Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) reverses metabolic syndrome-induced cardiac alteration through changes in mitochondrial biogenesis, dynamics and autophagy. METHODS AND RESULTS Mice were fed...

BACKGROUND/AIMS Carbon monoxide (CO) interferes with cytochrome-dependent cellular functions and acts as gaseous transmitter. CO is released from CO-releasing molecules (CORM) including tricarbonyl-dichlororuthenium (II) dimer (CORM-2), molecules considered for the treatment of several disorders including vascular dysfunction, inflammation, tissue ischemia and organ rejection. Cytochrome P450-s...

OBJECTIVE Damage to intestinal epithelial tight junctions plays an important role in sepsis. Recently we found that Carbon Monoxide-Releasing Molecule-2 (CORM-2) is able to protect LPS-induced intestinal epithelial tight junction damage and in this study we will investigate if CORM-2 could protect intestinal epithelial tight junctions in the rat cecal ligation and puncture (CLP) model. MATERI...