Introduction: Ethanol can induce a wide spectrum of neurophysiological effects via interaction with multiple neurotransmitter systems and disruption of the balances between inhibitory and excitatory neurotransmitters. Prefrontal cortex is involved in cognitive process including working memory and is sensitive to ethanol. Present study investigates the effects of intraperitoneal (i.p.) admini...

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned t...

Previous studies have shown that the receptive field properties, spontaneous activity and spatio-temporal interactions of low-threshold mechanical somatosensory cells in the barrel cortex are influenced by C-fibers. In this study, we examined the effect of C-fiber depletion on response properties of barrel cortex neurons following experience dependent plasticity. Methods: In this study, exte...

objective(s): the dopamine level of the nucleus accumbens changes during some stereotyped behaviors. to study dopamine level of the nucleus accumbens in intra infralimbic apomorphine-induced climbing, microdialysis probes were implanted into the nucleus accumbens shell of male sprague dawley rats weighting 275–400 g.   materials and methods: the rats were divided into two groups (apomorphine an...

background and aim: auditory temporal resolution skill is calculated according to the minimum required time to analyze or integrate acoustic events. this skill, which is essential for speech perception, was evaluated by gap detection tests. the aim of this study was to determine the presence or absence of any differences between the right and left ear in the gap detection test. methods: after p...

ôbjective: ëmotional intelligence (ëï) is a set of competencies that enable us to engage in sophisticated information processing of emotions and emotion-relevant stimuli and to use this information as a guide for thinking and behavior. prefrontal cortexes (pfç) of brain and related regions have an important role in emotion and emotional regulation. âccordingly, we conducted a study to investiga...

delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...

One of the most important factors in drug addiction is stress. It has been shown that animals with prenatal stress history are more risky for drug dependence. It have also been shown that frontal cortex play a role in drug dependence. In the present study the effects of two kinds of mild stress during pregnancy on the development of frontal cortex in Wistar rats (250-300 g) were investigated. F...