INTRODUCTION Osteoporosis is seen in some 12-50 % patients with liver cirrhosis. Detrimental effects of alcohol are exerted directly on the bone cells and indirectly on hormones. Vitamin D is involved in osteoblast differentiation, bone matrix synthesis and bone mineralization, as well as in its decomposition. Vitamin D deficiency has been reported in about 2/3 patients with liver cirrhosis. ...

It is well known that patients with recurrent calcium nephrolithiasis present bone mineral density loss manifesting as osteopenia or osteoporosis in the lumbar spine and/or hip.1 Moreover, it has been observed that in patients with calcium stones and idiopathic hypercalciuria, higher levels of fasting calcium/creatinine increase the possibility of osteopenia, therefore there is a risk factor fo...

BACKGROUND Reduced bone mineral density (BMD) is commonly found in alcohol-dependent patients. Many risk factors have been reported, yet the course of markers of bone formation and resorption in abstinent alcoholic patients have not received much attention. METHODS In a prospective longitudinal study, we investigated BMD in male abstinent inpatients of an alcohol rehabilitation clinic aged 21...

BACKGROUND Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined. METHODOLOGY/PRINCIPAL FINDINGS We conducted a post-hoc analysis of ...

Objectives: To establish reference ranges for serum bone turnover markers including Osteocalcin (OC), Procollagen type 1 amino-terminal propeptide (P1NP), and Beta-CrossLaps (beta-CTX) in premenopausal women at University Medical Center, Ho Chi Minh City. Methods: A cross-sectional study was conducted on 157 aged 20 to 44 years City from December 2022 February 2023. Demographic information, bio...

Background The mechanism of osteoporosis in rheumatoid arthritis (RA) is multifactorial. However, inflammation and autoimmunity are key players in its pathogenesis. Treatment with tumour necrosis factor alpha (TNFa) blockers has been shown to be beneficial for bone metabolism and they were able to prevent bone deformities in RA. Moreover, they improved the bone mineral density (BMD) [1]. Howeve...

OBJECTIVE Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin ...