BACKGROUND Few natural products have demonstrated the range of protective and therapeutic promise as have turmeric and its principal bioactive components: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Success in translating this potential into tangible benefits has been limited by inherently poor intestinal absorption, rapid metabolism, and limited systemic bioavailability. Seeking to ...

Natural tyrosinase inhibitors from herbal plants are promising therapeutic agents for skincare and cosmetic products. curcuminoids exhibit weak antityrosinase properties. The structural modification of curcumin, the major curcuminoid Curcuma longa, gave 14 analogues. inhibitory activity natural modified analogues on both L-tyrosine DOPA substrates were evaluated. inhibition kinetics also undert...

The dried, ground rhizome of turmeric (Curcuma longa) has been used in Asian medicine for centuries. This perennial plant in the ginger family is cultivated throughout the tropics and is used as both a spice and to support health. Curcumin is a term that is sometimes used to refer to any or all of the curcuminoid compounds in turmeric. There are three main curcuminoids in turmeric, of which cur...

Novel red-to-NIR fluorophores called Nanchang Red (NCR) dyes have been constructed by rational structural hybridization of cyanine and borondifluoride curcuminoid. The peculiar asymmetrical layout the three key fragments endows these long-wavelength with ideal photophysical properties ER self-targeting capability. photoluminescent mechanism, revealed quantum chemical calculations, will greatly ...

BACKGROUND Small dense low-density lipoprotein (sdLDL) is a sub-fraction of LDL considered to have the most atherogenic properties. The present trial aimed to assess changes in circulating sdLDL concentrations following supplementation with curcuminoids, polyphenolic compounds with diverse potential cardio-protective functions. METHODS This study was designed as a randomized double-blind plac...