نتایج جستجو برای: curcuminoid

تعداد نتایج: 361  

2013
John Cuomo Giovanni Appendino Adam S. Dern Erik Schneider Toni P. McKinnon Mark J. Brown Stefano Togni

ABSTRACT: The relative absorption of a standardized curcuminoid mixture and its corresponding lecithin* formulation (Meriva) was investigated in a randomized, double-blind, cross-over human study. Clinically validated dosages were used for both products, and plasma levels of all three major curcuminoids (curcumin), demethoxycurcumin, and bisdemethoxycurcumin were evaluated. Total curcuminoid ab...

2016
P. A. Astawa

Received April 5, 2016 Revised May 20, 2016 Approved May 27, 2016 Bali Pig is one of germplasm whose existence is very limited until now. This is due to the very low growth and breeding compared to other types such as Landrace pigs, Duroc, and Laghwhite. However, Bali pig has an advantage among others such as able to utilize lack quality feed so it is suitable to maintain in a rural areas. To k...

Journal: :Journal of natural products 2011
John Cuomo Giovanni Appendino Adam S Dern Erik Schneider Toni P McKinnon Mark J Brown Stefano Togni Brian M Dixon

The relative absorption of a standardized curcuminoid mixture and its corresponding lecithin formulation (Meriva) was investigated in a randomized, double-blind, crossover human study. Clinically validated dosages were used for both products, and plasma levels of all three major curcuminoids [curcumin (1a), demethoxycurcumin (1b), and bisdemethoxycurcumin (1c)] were evaluated. Total curcuminoid...

Journal: :Current pharmaceutical design 2013
Laura E Wright Jen B Frye Bhavana Gorti Barbara N Timmermann Janet L Funk

While the chemotherapeutic effect of curcumin, one of three major curcuminoids derived from turmeric, has been reported, largely unexplored are the effects of complex turmeric extracts more analogous to traditional medicinal preparations, as well as the relative importance of the three curcuminoids and their metabolites as anti-cancer agents. These studies document the pharmacodynamic effects o...

Journal: :Acta medica Indonesiana 2012
Nyoman Kertia Ahmad H Asdie Wasilah Rochmah Marsetyawan

AIM to assess the ability of curcuminoid from Curcuma domestica Val in reducing the cycloxygenase-2 secretion by synovial fluid's monocytes compared to diclofenac sodium in patients with osteoarthritis. METHODS this was a prospective randomized open end blinded evaluation (PROBE) study. The subjects were patients with knee osteoarthritis who were divided randomly into two groups, the first gr...

2015
Hong-Bin Chang Bing-Huei Chen

The objectives of this study were to explore the inhibition mechanism of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus. In addition, human bronchus epithelial cell line BEAS-2B (normal cell) was selected for comparison. A high-performance liquid chromatography (HPLC) method was developed to separate and quantify the various curcum...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2008
Laurie P Volak Senait Ghirmai John R Cashman Michael H Court

Curcuminoid extract and piperine are being evaluated for beneficial effects in Alzheimer's disease, among other intractable disorders. Consequently, we studied the potential for herb-drug interactions involving cytochrome P450 (P450), UDP-glucuronosyltransferase (UGT), and sulfotransferase (SULT) enzymes. The curcuminoid extract inhibited SULT > CYP2C19 > CYP2B6 > UGT > CYP2C9 > CYP3A activitie...

Journal: :Nutrition and cancer 2016
Stephan Dützmann Christina Schiborr Alexa Kocher Ulrich Pilatus Elke Hattingen Jakob Weissenberger Florian Geßler Johanna Quick-Weller Kea Franz Volker Seifert Jan Frank Christian Senft

BACKGROUND The oral bioavailability of curcuminoids is low, but can be enhanced by incorporation into micelles. The major curcuminoid curcumin has antitumor effects on glioblastoma cells in vitro and in vivo. We therefore aimed to determine intratumoral concentrations and the clinical tolerance of highly bioavailable micellar curcuminoids in glioblastoma patients. METHODS Thirteen glioblastom...

2015
Chih-Chang Yeh Yu-Han Su Yu-Jhe Lin Pin-Jyun Chen Chung-Sheng Shi Cheng-Nan Chen Hsin-I Chang

Curcumin (Cur) and bisdemethoxycurcumin (BDMC), extracted from Curcuma longa, are poorly water-soluble polyphenol compounds that have shown anti-inflammatory potential for the treatment of osteoarthritis. To increase cellular uptake of Cur and BDMC in bone tissue, soybean phosphatidylcholines were used for liposome formulation. In this study, curcuminoid (Cur and BDMC)-loaded liposomes were cha...

This experiment was conducted to evaluate the effect of graded dietary levels of pure curcuminoid on productive performance, egg quality traits, some biochemical blood parameters, immune response and its digestibility in the late phase of production of laying hens. A total of 160 sixty-weeks-old Hy-Line (W-36) laying hens were used in a completely randomized design, including 4 treatments in fo...

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