the aim of this study was assessing the adjuvant therapy of exercise on cytokines balance in mice with breast cancer tumor. twenty female balb/c mice were randomly assigned to experimental and control groups. after orientation in the environment, estrogen-receptor dependent breast cancer cells (mc4-l2) were injected to them and experimental group performed endurance training 5 day in week for 6...

background: leishmania is a significant health problem in many parts of the world. tumor necrosis factor (tnf) plays an essential role in leishmania major infections. objective: to study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients. methods: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (r...

Introduction: Pro-inflammatory cytokines, such as IL-1b and TNF- α have been suggested to be involved in the pathophysiology of depression. Tricyclic antidepressants (TCAs) are also thought to influence immune functions and concentrations of cytokines. The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who were treated, not treated, or poisoned wit...

antifibrotic therapies should preferentially be targeted to the activated hepatic mesenchymal cells. those cells resemble wound healing myofibroblasts and synthesize an excess of extracellular matrix (ecm) proteins. they derive from quiescent hepatic stellate cells (hsc) and portal/perivascular (myo-) fibroblasts (mf). whereas various agents have been shown to inhibit hsc/mf proliferation and c...

background depression and sleep disorders are more prevalent among rotational shift workers than regular day workers. people with sleep disorders have higher inflammatory and pre-inflammatory cytokines than those in the control group. objectives the present study was conducted to investigate serum level of high sensitivity c-reactive protein (hscrp), interleukin-6 (il-6) and cortisol among depr...

background: cutaneous leishmaniasis is an endemic disease in many regions of iran, including the city of mashhad. in recent years, some cases have not responded to glucantime, the usual treatment for this disease. the cellular immune response caused by t-helper type 1 (th1) cells has an important role in protection against leishmaniasis, and activation of the t-helper type 2 (th2) response caus...

background there is a strong relationship between physical inactivity and low-grade inflammation and its adverse health outcomes, particularly cardiovascular disease. the level of anti-inflammatory and pro-inflammatory cytokines may be changed by exercise. objectives the aim of the present study was to determine the response of certain inflammatory biomarkers to exercise with differences in max...