Abstract This study aimed to obtain the optimum formula of Chlorella milk with D-Optimal Mixture Design and determine consumer preference for formula. research method was divided into formulation response design, hedonic test, analysis, optimization, verification The determined based on highest score taste. Two solutions were obtained, it found that 0.40% + 0.05% vanillin 4.55% sugar most prefe...

We study the consistency of parameter estimators in adaptive designs generated by a onestep ahead D-optimal algorithm. We show that when the design space is finite, under mild conditions the least-squares estimator in a nonlinear regression model is strongly consistent and the information matrix evaluated at the current estimated value of the parameters strongly converges to the D-optimal matri...

Abstract Multiple Sclerosis (MS) is one of the most common neurological disorders diagnosed in young adults. there are no current cures for the disease or its underlying causes, some drugs have been developed that can decrease or delay disease progression. Fingolimod is an immunomodulating drug, mostly used for treating multiple sclerosis (MS). It approximately halves the rate of relapse ...

D-optimal regression designs under random block-e ects models are considered. In addition to selecting design points, an experimenter also needs to specify how they are grouped into blocks. We rst consider minimum-support designs, which are supported on the minimum number of design points. In this case, it is shown that a D-optimal design can be obtained by combining a D-optimal block design (f...

in acceptance-sampling plans, the items of an incoming lot are inspected one by one. if the number of nonconforming items in sample is equal zero, the lot is accepted but if the number of nonconforming items is equal to one, then second sample is taken and the policy of zero acceptance number would be applied for the second sample. in this paper, a mathematical model is developed to design sing...