Studies performed in vivo have been controversial regarding the implication of human apolipoprotein (apo)A-II in the atherogenic process. Expression of human apoA-II in transgenic mice fed a chow diet leads to (1) a bimodal distribution of high density lipoprotein (HDL) size as in humans, (2) a reduction in total cholesterol concentration that is mainly due to a reduction in non-HDL cholesterol...

Objective: Brown fat activation attenuates atherosclerosis development by accelerating triglyceride-rich lipoprotein turnover and/or stimulation of reverse cholesterol transport via the SRB1 (scavenger receptor class B type 1). The aim this study was to investigate specific role hepatic in atheroprotective properties brown activation. Approach and Results: APOE*3-Leiden.CETP mice, a well-establ...

INTRODUCTION A low level of high-density lipoprotein cholesterol (HDL-C) is an established predictor of the risk of coronary heart disease (CHD). HDL promotes cellular cholesterol efflux and reverse cholesterol transport from lipid-laden macrophages (Figure 1), and prevents lipoprotein oxidation. A linear inverse relation has been reported in many observational studies between plasma HDL-C leve...

The fractional esterification rate of cholesterol in apolipoprotein B (apoB)-depleted plasma (FER(HDL)) is a good indicator of particle size distribution in high density lipoprotein (HDL) and low density lipoprotein (LDL). However, there has been a discrepancy in the absolute values of FER(HDL) published by different laboratories. Because the main difference between the methods was in the label...

High density lipoprotein (HDL) receptor activity was decreased by the addition of platelet-derived growth factor (PDGF) to cholesterol-loaded cultured human skin fibroblasts. Effects were observed within 12 hours, coinciding with increases in tritiated thymidine incorporation into DNA. The PDGF-mediated decrease in HDL binding was associated with a decrease in cholesterol efflux promoted by HDL...

OBJECTIVES Elevated blood cholesterol levels are a major risk factor for coronary artery disease, the leading cause of death worldwide. Probiotics have been investigated as potential cholesterol-lowering therapies, but no previous studies have assessed the effect of the probiotic yeast Saccharomyces boulardii on cholesterol levels in human volunteers. The objective of this study was to examine ...

Objective Dyslipidemia and insulin resistance (IR), occurring in most infertile women with polycystic ovarian syndrome (PCOS), increase the risk of cardiovascular disease (CVD) and type 2 diabetes. This study aimed to assess the relationships between lipoprotein ratios and IR in PCOS women. MaterialsAndMethods Thirty six infertile women with PCOS selected based on Androgen Excess Society (AES) ...

It is believed that the cyclic variations in sex hormones across the menstrual cycle may have effects on the lipid profile and hence on cardiovascular health. Thus, the purpose of study was to find out the serum levels of lipids and lipoprotein ratios in different phases of menstrual cycle in eumenorrheic women. One hundred and twenty young healthy female subjects of reproductive age group (17-...

When cultured human fibroblasts were incubated with medium of varying composition, the activity of the low density lipoprotein (LDL) receptor was strongly correlated with the amount of cholesterol that egressed from the cell. Particles isolated from lipoprotein-deficient serum (d > 1.25) by anti-apoprotein (apo) A-I affinity chromatography were as effective as the d > 1.25 serum in activating t...

The term plasma lipid profile considers measurement of certain components of plasma including total cholesterol (TCh), high density lipoprotein cholesterol (HDL-Ch), triglycerides (Tg), low density blipoprotein cholesterol (LDL-Ch) and very low density lipoprotein cholesterol (VLDL-Ch). TCh consists of all the cholesterol present in different lipoproteins like high density lipoprotein (HDL), lo...