A simple and rapid UV spectrophotometric method has been developed for simultaneous estimation of Metoprolol Succinate (MET) and Chlorthalidone (CLT). The absorbances of both drugs were found at 267nm and 243 nm in the range of 12-28 μg/ml (y=0.0024X+0.001; r =0.9996) and 3-7μg/ml (y= -0.0149x+0.0015; r = 0.9991) respectively for MET and CLT in methanol 2 2 solvent system.267 nm and 243 nm were...

Strontium ranelate is used for treatment of osteoporosis. The present work deals with method development for estimation of Strontium ranelate in bulk dosage form by UV spectrophotometry. A new simple, accurate and sensitive method for estimation of Strontium ranelate from bulk dosage form has been developed. The method employs zero order derivative spectroscopy. Estimation of Strontium ranelate...

Derivative spectrophotometric procedures and an isocratic high performance liquid chromatographic method for the determination of butamyrate citrate (Sinecod, Safarol) in cough syrups have been developed. In the spectrophotometric method, direct measurement of the drug at its absorption maxima is impossible because of interference from different absorbing excipients. Extraction of butamyrate ci...

The objective of this study was to develop simple, precise, accurate and sensitive UV spectrophotometric methods for the simultaneous determination of ofloxacin (OFX) and flavoxate HCl (FLX) in pharmaceutical formulations. The first method is based on absorption ratio method, by formation of Q absorbance equation at 289 nm (λmax of OFX) and 322.4 nm (isoabsorptive point). The linearity range wa...

A methods for the determination of fenbufen and ketoprofen in pharmaceuticals by classical spectrophotometry--zero order derivative, first and second order derivatives spectrophotometry is described. using "peak-peak" (P-P) and, "peak-zero" (P-O) measurements. The calibration curves are linear within the concentration range of 2.0 - 12.0 microg x mL(-1) for fenbufen and ketoprofen. The procedur...

Three simple and rapid spectrophotometric methods were developed for detection and trace determination of benzophenone (the main impurity) in phenytoin bulk powder and pharmaceutical formulations. The first method, zero-crossing first derivative spectrophotometry, depends on measuring the first derivative trough values at 257.6 nm for benzophenone. The second method, zero-crossing third derivat...