in iran, the majority of vegetable oil producers , use pet for packaging their products . due to high solubility of pet oligomers in the oils , and shelf life of liquid oils , it is expected that some compounds migrate into the oil . this study was carried out to determine the amount of migration of terephtalates from pet bottles into sunflower oil and the effect of temperature and storage time...

Rapid, precise, accurate, and specific ratiospectra derivative spectrophotometry and a simple UV spectrophotometry using simultaneous equation methods are developed for the simultaneous determination of bisoprolol fumarate and hydrochlorothiazide from combined pharmaceutical dosage forms. For ratiospectra derivative spectrophotometry, the amplitudes were measured at 202.6 nm for bisoprolol fuma...

Amygdalin is a cyanogenic glucoside found in apricot kernels. To facilitate the exploitation and use of wild apricot resources, it is necessary to be able to rapidly and efficiently determine the amygdalin levels within their kernels. To do so, this paper compares two methods, one based on second-derivative UV spectrophotometry and the other on highperformance reversed-phase liquid chromatograp...

A method for determination of alendronate sodium salt, clodronate disodium salt and etidronate disodium salt in pharmaceutical formulation by direct UV-spectrophotometry and/or first and second derivative UV-spectrophotometry via complex formation with Cu (II) ions is described. The calibration graphs are linear in the range 25-600 mmol/L for all the investigated compounds. No interference was ...

UV, first, second and third derivative spectrophotometric methods have been developed for the determination of ezetimibe in pharmaceutical formulation. The solutions of standard and sample were prepared in methanol. For the first method, UV spectrophotometry, the quantitative determination of the drug was carried at 233 nm and the linearity range was found to be 6-16 mug/ml. For the first, seco...

In this study, derivative UV spectrophotometric methods were developed for the analysis of diflunisal, which is used as a nonsteroidal anti-inflammatory drug. Analysis wavelengths of diflunisal for the first and second order derivative UV spectrophotometric methods were obtained as 235.6 nm and 228.8 nm, respectively. The linearity ranges were found as 1.0-25.0 μg mL-1 for the first order and 1...

This paper presents a new methodology of quantitative determination of seven azole antifungal medicines widely used in therapy. Analyses were performed directly by using zero-order (fluconazole), first derivative (bifonazole, clotrimazole, econazole, itraconazole, miconazole) and second derivative (ketoconazole) UV spectrophotometry. Validation of all methods confirms their proper precision (%R...

PURPOSE This study was designed to develop and validate two simple, rapid, and economical UV-spectrophotometric and the first-order derivative methods using the area under curve method for estimation of diacerein in bulk and in capsule formulation. MATERIALS AND METHODS In this study, hydrotrophic solution of 8 M urea and 0.5 M potassium citrate were employed as the solubilizing agent to solu...

Two rapid, simple, sensitive, selective and economic derivative spectrophotometric (first [D1] and second [D2]) and synchronous spectrofluorimetric (FDSFS and SDSFS) methods have been developed for the analysis of fexofenadine hydrochloride (FXD) in the presence of its different degradation products. Derivative spectrophotometry (D1) was used to measure FXD at 223 nm in the presence of its alka...