Objectives: Cardioplegic arrest during cardiac surgery induces severe abnormalities of the pyruvate metabolism, which may affect functional recovery of the heart. We aimed to evaluate the effect of pyruvate and dichloroacetate administration during reperfusion on recovery of mechanical function and energy metabolism in the heart subjected to prolonged cardioplegic arrest. Methods: Four groups o...

Background: The diabetic heart has an increased susceptibility to cardiovascular disease with alterations in cardiac metabolism considered an important contributor. Pyruvate dehydrogenase (PDH) is a key regulatory enzyme in the metabolism of glucose and its activity is reduced in diabetes. Dichloroacetate (DCA) is a potent activator of PDH and it has previously been shown to normalise blood glu...

Dichloroacetate selectively improves cardiac function and metabolism in female and male rainbow 1 trout 2 3 Pavan K. Battiprolu* and Kenneth J. Rodnick 4 5 6 Department of Biological Sciences, Idaho State University, Pocatello, ID 83209-8007 7 8 *Current address: Department of Metabolic disorders, Amgen, Inc. South San Francisco, CA 94568. 9 10 Corresponding author. e-mail: [email protected]; ph...

Dichloroacetate (DCA) is a xenobiotic of interest to both environmental toxicologists and clinicians. The chemical is a product of water chlorination and of the metabolism of various drugs and industrial chemicals. Its accumulation in groundwater and at certain Superfund sites is considered a potential health hazard. However, concern about DCA toxicity is predicated mainly on data obtained in i...

Lactic acidosis remains a life-threatening condition in man (Cohen & Woods, 1976). It may be caused by inhibitors of gluconeogenesis such as phenformin (l-phenethylbiguanide), by severe liver disease, by agents such as fructose and ethanol or by combination of these factors. We have previously shown that experimental lactic acidosis secondary to phenformin administration could be prevented or r...