The key to a successful long-term outcome in patients with hemophilia is an efficient prophylaxis that prevents bleeding in joints for children and adults with hemophilia. Efficient prophylaxis requires taking into account the available resources (clotting factor concentrate, trough levels), the bleeding trigger (activity levels, chronic synovitis, already existing arthropathy), and most import...

Rheumatic fever and rheumatic heart disease continue to be major public health problems in the developing world, particularly in the countries of sub-Saharan Africa. Because of its cost effectiveness, secondary prophylaxis is advocated as the principal means of disease prevention and control. However, in developing countries, valvular damage, due to earlier, unrecognized episodes of rheumatic f...

Early case detection is now seen as one of the most important tasks for leprosy programs. It can improve experience people who develop disease, early treatment prevents many complications that frequently occur in whose diagnosis delayed. also an factor efforts to prevent ongoing transmission, reduces spread close contacts. Perhaps more importantly, it provides a platform appropriate management ...

INTRODUCTION Opportunistic infections can occur in up to 40% of people with HIV infection and a CD4 count less than 250/mm(3), although the risks are much lower with use of highly active antiretroviral treatment. METHODS AND OUTCOMES We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of prophylaxis for Pneumocystis jirovecii pneumonia (...

Abstract Background Cytomegalovirus (CMV) causes significant morbidity in solid organ transplant recipients (SOTR). As a lack of immunity predisposes to infection, laboratory test that measures CMV-specific cell-mediated (CMV CMI) may help guide antiviral prophylaxis, predict relapses and correlate with outcomes. We assessed CMV CMI D+/R- patients during valganciclovir primary prophylaxis virem...

A total of70 children aged 6 to 15 years with rheumatic fever and completed in-hospital data were reviewed from 19XX to 1993. In 5X.6% of patients this was the first attack of disease, while in 41.4'10 the episode represented a recurrence. Noncompliance of antimicrobial prophylaxis was noted in all of the subjects with recurrences. 61.4% of cases gave a previous history of sore throat, and ...