Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...

objective(s): coronary artery disease (cad) is the leading cause of death in both male and female worldwide. the main cause of cad is the atherosclerosis of coronary arteries, which is, mostly caused by genetic alteration. 50% of such cases occur in mitotic cells where single-strand breaks occur spontaneously or due to ionizing radiation. x-ray repair cross-complementing protein 1 (xrcc1) as a ...

background: lymphocytes of fanconi anemia (fa) show an increased sensitivity to the alkylating agents such as mitomycin c (mmc), but their responses to gamma-irradiation is controversial. the extent of dna damage in leukocytes of fa patients following irradiation and mmc treatment was studied at cellular and single chromosome level. methods: dna damage induced by gamma-rays and mmc was measured...

background: differentiation ofmesenchymal stem cells (mscs) to hepatocyte-like cells could be associated with development of liver function factors. the impact of differentiation-dependent changes on dna integrity is not well understood. in this study, hepatocytes and their progenitor stem cells were treated with aflatoxin b1 (afb1) and amplification of selected genes linked to dna damage was e...

Objective: The discovery and development of natural products with potent antioxidant properties has been one of the most interesting and promising approaches in the search for treatment of CNS injuries. The most significant consequence of the oxidative stress is thought to be the DNA modifications, which can become permanent via the formation of mutations and other types of genomic instability ...

Background: Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial. The extent of DNA damage in leukocytes of FA patients following irradiation and MMC treatment was studied at cellular and single chromosome level. Methods: DNA damage induced by gamma-rays and MMC was measure...

Introduction: Radiotherapy is still one of the main options for cancer treatment but it is in association with damage to normal cells as well as the tumor cells. To reduce the injury in normal cells we have evaluated the effect of 528 hertz sound after X irradiation in peripheral blood lymphocytes. Materials and Methods: in this study, peripheral blood was o...

Background There has been a growing claim about the stress induced by the modern life and especially by cell phones. It may have detrimental effect on sperms. We examined the relationship of stress caused by cell phone radiation and the effect of Zinc and Alpha-tocopherol on the sperms and its chromatin in this condition. MaterialsAndMethods Fresh semen has been collected from 20 young men. Eac...