Goel, Danny P., Thane G. Maddaford, and Grant N. Pierce. Effects of -3 polyunsaturated fatty acids on cardiac sarcolemmal Na /H exchange. Am J Physiol Heart Circ Physiol 283: H1688–H1694, 2002; 10.1152/ajpheart.00664. 2001.—Myocardial ischemia-reperfusion activates the Na /H exchanger, which induces arrhythmias, cell damage, and eventually cell death. Inhibition of the exchanger reduces cell da...

The epithelial sodium channel is found in apical membranes of a variety of native epithelial tissues, where it regulates sodium and fluid balance. In vivo, a number of hormones and other endogenous factors, including polyunsaturated fatty acids (PUFAs), regulate these channels. We tested the effects of essential n-3 and n-6 PUFAs on amiloride-sensitive sodium transport in A6 epithelial cells. E...

Aquatic animals are important to health-conscious consumers due to their high content of polyunsaturated fatty acids (PUFA) particularly omega-3 FA. This paper reports the fat contents and fatty acid profiles of 20 species of marine fish and 6 species of squid and shrimp (obtained in the fishing port of Pattani, Thailand), in addition to 7 types of Thai freshwater fish to create a fatty acid da...

S PERMATOZOA from the caput, corpus and cauda epididymis and ejaculated sperm were analyzed for their phospholipid and phospholipid fatty acid content. Caput spermatozoa contained 16 and 34% more total phospholipid than sperm from the corpus and cauda epididymis, respectively. Caudal sperm were similar to ejaculated sperm in phospholipid content. Seminal plasma from ejaculated semen collected a...

We investigated peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands effect on cell motility and the plasminogen activator system using normal MCF-10A and malignant MCF-10CA1 cell lines. Ciglitazone reduced both wound-induced migration and chemotaxis. However, the effect was not reversed with pretreatment of cells with the PPAR-γ-specific antagonist GW9662. Immunoblot analysis of condi...

Twenty male patients with primary hypertriglyceridemia were treated for 4 weeks with daily supplements (15 g) of oil, which provided approximately 6 g of polyunsaturated fatty acid (PUFA) either of fish or of vegetable origin. Total plasma cholesterol concentrations were unaffected, but both types of supplement increased high density lipoprotein-3 (HDL3) cholesterol concentrations. The fish, bu...

Peroxisomes are essential organelles exerting key functions in fatty acid metabolism such as the degradation of very long-chain fatty acids (VLCFAs). VLCFAs accumulate in X-adrenoleukodystrophy (X-ALD), a disease caused by deficiency of the Abcd1 peroxisomal transporter. Its closest homologue, Abcd2, exhibits a high degree of functional redundancy on the catabolism of VLCFA, being able to preve...

This article reviews research on the growth and nutrient intake of vegan children and provides guidelines for counselling parents of vegan children. Although diets of vegan children meet or exceed recommendations for most nutrients, and vegan children have higher intakes of fiber and lower intakes of total fat, saturated fat, and cholesterol than omnivore children, some studies indicate that th...

The objective of this study was to investigate whether short-term zinc deficiency in the early neonatal period would exacerbate the effects of essential fatty acid (EFA) deficiency on liver and brain long-chain polyunsaturated fatty acid (LCPUFA) composition, as well as on behavioral development in artificially reared rat pups. Using a 2 3 2 factorial design, male Long-Evans rat pups were reare...