Adenoviral vectors have shown a great potential for vaccine development due to their inherent ability to induce potent and protective CD8 T-cell responses. However, a critical issue regarding the use of these vectors is the existence of inhibitory immunity against the most commonly used Ad5 vector in a large part of the human population. We have recently developed an improved adenoviral vaccine...

Inverse model based multiobjective evolutionary algorithm aims to sample candidate solutions directly in the objective space, which makes it easier to control the diversity of non-dominated solutions in multiobjective optimization. To facilitate the process of inverse modeling, the objective space is partitioned into several subregions by predefining a set of reference vectors. In the previous ...

Many mosquito-borne arboviruses have more than one competent vector. These vectors may or may not overlap in space and time, and may interact differently with vertebrate hosts. The presence of multiple vectors for a particular virus at one location over time will influence the epidemiology of the system, and could be important in the design of intervention strategies to protect particular hosts...

Suppose Si is a finite set of pure strategies for players i D 1; : : : ; n in normal form game G, so that S D S1 : : : Sn is the set of pure strategy profiles for G, and i .s/ is the payoff to player i when strategy profile s 2 S is chosen by the players. We denote the set of mixed strategies with support in S as mS D S1 : : : Sn, where Si is the set of mixed strategies for player i with suppor...

introduction: cutaneous leishmaniasis is a parasitological disease that is spread in many tropical and subtropical areas in world. this disease transmitted by female sand flies. it is clear that knowledge on sand flies ecology has the main role to planning of control of cl. this study was carried out for determination of cl vectors, in ghanavat district in qom province during 2012. material and...

Ritz method is one of the techniques for reduction of the degrees of freedom. Efficiency of Ritz method depends on used vectors. The Ritz method uses load depended vectors in spite of modal method and for this reason it is expected to give better results than modal method. This is the advantage of Ritz method. It is worth mention that the mode shapes are independent of loading. The vectors that...

The fuzzy structured element (FSE) theory is a very useful toolfor dealing with fuzzy multi-criteria decision making (MCDM)problems by transforming the criterion value vectors of eachalternative into the corresponding criterion function vectors. Inthis paper, some concepts related to function vectors are firstdefined, such as the inner product of two function vectors, thecosine of the included ...

In multi-objective bilevel optimisation problems, the upper-level performance of different lower-level optimal solutions may be very different, even though they belong to same problem. It lead poor results. Therefore, search should non-dominated that are also in objective space. this paper, we use two populations search. The first population maintains non-dominance and diversity space provides ...