Radio-sensitization with gold nanoparticles (GNPs) is a relatively recent advancement of radiotherapy that determined to increase radiation in the target tumor region. Monte Carlo (MC) simulation well-known method has gained popularity by assisting determining effective dose various tumors. Assessing concentration particles during proton therapy can provide key evaluating efficiency performed t...

Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lyi...

Introduction: In the present study, AS1411 aptamer conjugated gold nanoclusters (GNCs) have been introduced as a targeted radiosensitizer for enhancing megavoltage radiation therapy efficacy. RT has identified as an effective therapeutic modality for many different types of solid tumors. However, equal radiation beams absorption by tumor and surrounding healthy tissues is still...

The aim of the present Monte Carlo study is to evaluate the variation of energy deposition in healthy tissues in the human eye which is irradiated by brachytherapy sources in comparison with the resultant dose increase in the gold nanoparticle (GNP)-loaded choroidal melanoma. The effects of these nanoparticles on normal tissues are compared between 103Pd and 125I as two ophthalmic brachytherapy...

Background: Dosimetry is a fundamental part of the radiation processing industry. Aqueous inorganic dosimeters have been used for gamma radiation dosimetry such as standard ferrous sulfate dosimeter. The purpose of this study was to investigate the effect of gamma radiation on the diethyl fumarate DEF in dimethyl sulfoxide DMSO solution and its possible use in chemical dosimetry. Materials and ...

Introduction: External radiotherapy is the most common method of radiotherapy which the most important problem associated with is that there is no difference between healthy and tumor tissues in dose absorption. One way to differentiate the dose sensitivity is to use metal-based nanoparticles. Bismuth oxide nanoparticles are good candidates for cancer radiotherapy. In this study, we investigate...

background: gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. objective: the aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles gnps with x-rays as a function of nanoparticle size and beam energy and ...

one of the applications of gold nanoparticles (gnps) in medicine is radiation dose-enhancing effect. although there are many simulations, in vitro and in vivo evidence that gnps can enhance significantly the radiation dose effect of orthovoltage beams. these beams compared with megavoltage (mv) beams, have limited applications in radiotherapy. in order to evaluate gnps radiosensitization perfor...

Introduction: Bismuth-based nanoparticles having high atomic number and electron density, besides of being utilized as CT contrast agent, stand as a strongly proposed method for dose enhancement in radiotherapy. Embedded nanoparticle in polymer gel dosimeter poses the first step to assess the dose enhancement capability in nanoparticles. To this end, MAGICA gel dosimeter, whic...