in this study, the interaction of the anthracycline antibiotic doxorubicin with dna-hmg 1 complex was investigated employing uv/vis spectroscopy, thermal denaturation and dna cellulose chromatography techniques. the results indicated that the binding of doxorubicin to the protein reduces its tm in a dose dependent manner. although doxorubicin protects free dna against thermal denaturation in th...

Although ion-exchange resins have been used widely as drug delivery systems, their exact release kinetics has not been reported yet. Usually only the rate-limiting step has been taken into account and the rest of the steps have been ignored as instantaneous processes. To investigate the exact release kinetics of polymer-coated drug/ion-exchange resin complexes for sustained drug delivery, the r...

To answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. In the present paper, controlled metal based drug (Pd(II) complex) release manner of β‑Lactoglobulin (β-LG) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...

Tinidazole is a broad spectrum antiprotozoal agent having bitter taste. The present study concerns to mask the bitter taste of tinidazole as an orally disintegrating tablet (ODT) using Indion 294 and Indion 204 (ion exchange resin) as a taste masking agent. In first method, 1:1, 1:2 and1:3 ratios of drug and resin were stirred for six hour. Percent drug losses were found to be on higher side in...

Methotrexate accumulated in the leukemic cells of two of four patients in excess of the concentration expected from the level of inactivated folate reducÃ-aseand could not be removed from the cell lysates by the aniÃ3nexchange resin Dowex 2-X8. In one of these two patients, free folate reducÃ-asewas assayed in the same cell lysates which, when boiled, appeared to contain an excess of a pharmaco...

Sodium polystyrene sulfonate (SPS), an ion-exchange resin designed to bind potassium in the colon, was approved in 1958 as a treatment for hyperkalemia by the US Food and Drug Administration, 4 years before drug manufacturers were required to prove the effectiveness and safety of their drugs. In September 2009, citing reports of colonic necrosis, the Food and Drug Administration issued a warnin...

3-Hydroxypropionaldehyde (3HPA) is an important C3 chemical that can be produced from renewable glycerol by resting whole cells of Lactobacillus reuteri. However the process efficiency is limited due to substrate inhibition, product-mediated loss of enzyme activity and cell viability, and also formation of by-products. Complex formation of 3HPA with sodium bisulfite and subsequent binding to Am...