Fragile X Syndrome (FXS), the most prevalent form of inherited intellectual disability and the foremost monogenetic cause of autism, is caused by loss of expression of the FMR1 gene . Here, we show that dfmr1 modulates the global metabolome in Drosophila. Despite our previous discovery of increased brain insulin signaling, our results indicate that dfmr1 mutants have reduced carbohydrate and li...

The present study was purported to standardize the high-resolution respirometry technique for the analysis of oxidative phosphorylation (OXPHOS) in saponin-skinned cardiac fibers. Preparation of permeabilized myocardial fibers allows the assessment of respiratory function of the entire population of mitochondria in their normal intracellular position. Adult male rat ventricular bundles were per...

The mitochondrial electron transport system (ETS) is a main source of cellular ROS, including hydrogen peroxide (H₂O₂). The production of H₂O₂ also involves the mitochondrial membrane potential (ΔΨm) and oxygen consumption. Impaired insulin signaling causes oxidative neuronal damage and places the brain at risk of neurodegeneration. We evaluated whether insulin signaling cross-talks with ETS co...

Although seasonal modifications of brown adipose tissue (BAT) in hibernators are well documented, we know little about functional regulation of BAT in different phases of hibernation. In the 13-lined ground squirrel, liver mitochondrial respiration is suppressed by up to 70% during torpor. This suppression is reversed during arousal and interbout euthermia (IBE), and corresponds with patterns o...

abstract background: endotracheal suctioning (ets) is an essential procedure performed for mechanically ventilated patients. ets can be either performed by open or closed suctioning system (css). there may be some concern on how closed‑system ets is practiced by intensive care nurses. this study was designed to investigate closed‑system ets practices of critical care nurses and to compare their...

Marine microplastics pollution is a major environmental concern in marine ecosystems worldwide, yet the biological impacts of on coastal biota are not fully understood. We investigated impact suspended energy budget mussels Mytilus coruscus using Cellular Energy Allocation (CEA) approach. The were exposed to control conditions (no microplastics) or one three concentrations 2 μm polystyrene micr...

Mycobacterium marinum produces carotenoids when exposed to light or when antimycin A is added. Structural characteristics of antiiycin A in relationship to its induction of carotenoid synthesis were determined in order to make comparisons with the characteristics required for its inhibition of the electron transport system. All four components of the antimycin A complex (AI, Az, AZ, and A4) wer...

in this paper, nano fibers (engelhard corporation titanosilicate number 10 / polyacrylonitrile) ets-10 / pan, as a composite exchanger to absorb heavy metals, were synthesized and optimized. several parameters were affected on this absorption. results show that the optimization sizes of the nano fibers are about 75 nanometers. structures were analyzed by scanning electron microscope (sem) and e...