PURPOSE To determine the effect of the base curve radius (BCR) of therapeutic soft contact lens (T-lens) on epithelial healing after laser-assisted subepithelial keratectomy (LASEK). METHODS Ninety-two eyes in 47 patients with myopia were prospectively evaluated after LASEK. All the patients wore T-lenses with the BCR (R1) randomly chosen after LASEK. The T-lenses were removed after complete ...

purpose: to evaluate the role of amniotic membrane transplantation (amt) in acute ocular chemical burns. methods: patients with grade ii-iv (gii-giv) ocular chemical burns (roper-hall classification) of less than two weeks’ duration underwent amt in addition to medical therapy. patients were followed for at least 6 months and evaluated for ocular pain, visual acuity, epithelial defect healing, ...

An experimental study examined the effect of basic fibroblast growth factor (bFGF) on the healing of corneal epithelial wounds in dogs. A corneal wound was made on one eye from each of 40 dogs with a corneal trephine (6 mm diameter). Four concentrations of bFGF (0, 0.1, 0.5, and 1.0 μg/ml) were applied to the affected eyes three times daily. Fluorescein staining was used to assess the closure o...

PURPOSE Protein kinase C (PKC) α plays a major role in the parasympathetic neural stimulation of lacrimal gland (LG) secretion. It also has been reported to have antiapoptotic properties and to promote cell survival. Therefore, the hypothesis for the present study was that PKCα knockout ((-/-)) mice have impaired ocular surface-lacrimal gland signaling, rendering them susceptible to desiccating...

PURPOSE To investigate the effects of topical application of the combination of substance P (SP) and insulin-like growth factor (IGF)-1 on corneal epithelial barrier function and epithelial wound closure in rats with capsaicin-induced neurotrophic keratopathy. METHODS Neonatal rats were injected subcutaneously with a single dose of capsaicin to induce neurotrophic keratopathy. Corneal epithel...

1 Rho kinases (ROCKs) Regulate Corneal Epithelial Wound Healing Jia Yin and Fu-Shin X. Yu From the Kresge Eye Institute, Departments of Ophthalmology, Anatomy and Cell Biology, Wayne State University School of Medicine, 4717 St. Antoine Blvd., Detroit, MI, 48201 Running head: Rho kinases in corneal epithelial wound healing

PURPOSE Patients with diabetes mellitus (DM) are at an increased risk for developing corneal complications, including delayed wound healing. The purpose of this study was to characterize the expression and the function of Serpine1 and other components of urokinase plasminogen activator (uPA)-proteolytic system in delayed epithelial wound healing in diabetic mouse corneas. METHODS Mice of the ...