Esophageal cancer, usually involve esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinoma (AC), is one of the most common malignant tumors in the world [1]. Esophageal cancer is the sixth leading cause of cancer death in the world [2]. Esophageal squamous-cell carcinoma and esophageal adenocarcinoma represent the core histological subtypes of esophagus cancer [3]. Esophageal car...

Younger patients (aged <30 years) presenting with esophageal cancer are rare. Bone marrow transplantation offers a curative therapy in patients with malignant and nonmalignant lymphohematopoietic diseases and other disorders. However, one important late complication in transplantation survivors is the development of secondary malignancies including solid tumors. Although some solid cancers have...

BACKGROUND Overexpression of PTK7 has been found in multiple cancers and has been proposed to serve as a prognostic marker for intrahepatic cholangiocarcinoma. Its role in esophageal cancer, however, remains to be clarified. We hypothesize that PTK7 positively regulates tumorigenesis of esophageal cancer. METHODS We examined PTK7 expression pattern in human esophageal squamous carcinoma by On...

Esophageal cancer is one of the most fatal diseases worldwide mainly because of its rapid progression and poor prognosis. Although the incidence of esophageal adenocarcinoma has markedly risen in North America and Europe in the past several decades, esophageal squamous cell carcinoma is still the predominant subtype of esophageal cancer, especially in China. It accounts for more than 90% of all...

Fas (APO-1/CD95) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand (FasL) or Fas antibody. In this study, we analyzed Fas and FasL expression in normal esophageal mucosa and esophageal squamous cell carcinomas. Reverse transcriptase-PCR revealed that Fas, soluble Fas, and FasL were expressed in all eight esophageal squamous carcinoma cell lines analyzed. Furtherm...

Background: In view of the low accuracy prognosis model esophageal squamous cell carcinoma (ESCC), this study aimed to optimize least squares support vector machine (LSSVM) algorithm determine uncertain prognostic factors using a Cloud model, and consequently, establish new high-precision ESCC.

The aim of this present study was to explore the expression and clinical significance of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) and enzymatic O-linked glycosylation (O-GlcNAcation) through the addition of O-linked-β-N-acetylglucosamine in esophageal squamous cell carcinoma. OGT expression and O-GlcNAcation in 40 samples from patients with esophageal squamous cell carcinoma wa...

BACKGROUND High expression of Bmi-1, a key regulatory component of the polycomb repressive complex-1, has been associated with many solid and hematologic malignancies including esophageal squamous cell carcinoma. However, little is known about the role of Bmi-1 in esophageal adenocarcinoma. The aim of this study is to investigate the amplification and high expression of Bmi-1 and the associated...

Cancer of the esophagus is the seventh leading cause of cancer death worldwide. Esophageal carcinoma cell lines are useful models to study the biological and genetic alterations in these tumors. An important prerequisite of cell line research is the authenticity of the used cell lines because the mistaken identity of a cell line may lead to invalid conclusions. Estimates indicate that up to 36%...

Esophageal cancer is a lethal disease with poor survival rate. It is necessary to determine the extension, and the stage of the tumor to predict the outcome of patients. Of the two common pathologic types, squamous cell carcinoma is still the most common form, and adenocarcinoma is the leading one. Early diagnosis and radical treatment of esophageal cancer, regardless of tumor spreading, increa...