Background: Mycobacterium tuberculosis lipid antigens take part in pathogenicity of the bacterium but the response of monocytes/macrophages to these antigens in tubercu-losis is not well known. Objective: The aim of current investigation was to study the M. tuberculosis lipid antigens in tuberculosis pathogenesis. Methods: In the present study M. tuberculosis lipid antigens were extracted. Mono...

Helicobacter pylori infections are accompanied with the release of some antigenic material into the stool. Outer membranes proteins (OMP) are among the major antigens of bacteria, which in comparison with other bacterial constituents have less cross-reactivity. In this study, OMP of H. pylori were isolated from 11 clinical isolates and rabbit antiserum against them was used to detect possible a...

Background: Tumor associated antigens can be viably used to enhance host immune response. Objectives: The immunomodulatory effect of biogenic selenium nanoparticles (SeNPs) was compared between treated and untreated mice with crude antigens of 4T1 cells. Materials and Methods: Female inbred BALB/c mice (60) were injected by cancinogenic 4T1 cells causing breast cancer. After 10 days, all tumor ...

the immune response to hepatitis b surface antigen (hbsag) is influenced by several factors, of which hla antigens and balanced secretion of th1/th2 cytokines play important roles. the aim of this study was to evaluate the influence of hla antigens on cytokine secretion by hbsag-stimulated peripheral blood mononuclear cells (pbmc) from healthy neonates vaccinated with recombinant hbsag. pbmcs w...

selective iga deficiency (igad) (serum iga concentration of pcr was used to type hla b, dr, and dq alleles in 29 iranian individuals with igad and 299 swedish individuals with igad. the results indicate a strong association with the hla b14, dr1 alleles in iranian subjects and hla b8, b12, b13, b14, b40, dr1, dr3, dr7, dq2 and dq5 alleles in swedish subjects. differences in hla association of i...

hiv infection by maternal transmission is increasing in the world due to the increase in infected women who are not receiving appropriate antiretroviral therapy. prognosis of hiv infection in children is poor because the newborn has an immature immune system. early diagnosis and therapy are needed to avoid the development of aids. new therapies are becoming available but prevention of infection...

Abstract A cognate antigen engagement of TCR induces a conformation change in the CD3 complex (CD3Δc) that is required for productive T cell activation. CD3Δc fails when TCRs interact with poorly immunogenic antigens, like many tumor-associated-antigens (TAAs), which do not active cells. Anti-CD3 monovalent Fab fragments (Mono-Fabs) bound to mimic CD3Δc, producing “co-potentiation” associated w...

background: sand fly saliva helps parasite establishment and induce immune responses in vertebrate hosts. in the current study, we investigated the modulation of phlebotomus papatasi salivary gland antigen expression by sea­sonal and biological factors. methods: sand flies were grouped according to physiological stages such as unfed, fed, semi-gravid, gravid, parous, nulliparous, infected or no...