Background: It has been reported that vitamin D has broad anti-inflammatory and immunomodulatory effects. Objective: To evaluate the effects of vitamin D on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). Methods: EAE was induced in C57BL/6 mice by immunization with myelin oligodendroglial glycoprotein mixed with complete Freund's adjuvant. The m...

BACKGROUND Experimental autoimmune encephalomyelitis (EAE) is used as an animal model for human multiple sclerosis (MS), which is an inflammatory demyelinating autoimmune disease of the central nervous system characterized by activation of Th1 and/or Th17 cells. Human autoimmune diseases can be either exacerbated or suppressed by infectious agents. Recent studies have shown that regulatory T ce...

Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of ho­mogenate the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true disease nervous system.
 Materials methods: studies were conducted on white nonlinear rats. To induce experimental aller­gic (EAE), homologous brain homogenates was used, which leads a...

Viral infections can exacerbate multiple sclerosis (MS) through poorly defined mechanisms. We developed an experimental system whereby infection with an asymptomatic neurotropic alphavirus caused a transient acceleration of experimental autoimmune encephalomyelitis (EAE) without altering the expansion or differentiation of autoreactive CD4+ T cells. Instead, this effect on the clinical course o...

Background: MicroRNAs are small noncoding RNAs that regulate gene expression and involve in many cellular and physiological mechanisems. Recent studies have revealed that dysregulation of microRNAs might contribute to autoimmune disorders such as multiple sclerosis. Based on these findings, we examined the potential role of miR-320 isoforms, miR-320-3p and miR-320-5p, in the context of autoimmu...

Abstract Multiple sclerosis (MS), an autoimmune disease of the central nervous system, is thought to be mediated by autoreactive CD4+ T cells producing IL-17A and IFNg. However, it unclear if these cytokines are essential for development, progression, or both. We have shown that neither IFNg nor IL-17A, alone, required development in experimental encephalomyelitis (EAE), a mouse model MS, but a...

Experimental autoimmune encephalomyelitis (EAE) is the most widely accepted in vivo animal model of Multiple sclerosis (MS). EAE model are most suitable for analysis of immunogenetic elements (major histocompatibility complex) and for the study of histological features (inflammation, demyelination and degeneration) of the disease for screening of new treatments for MS. Some approved medications...

Several matrix metalloproteinase (MMP) members contribute to pathology in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). As the role of MMP-12 in EAE has been understudied, we examined its expression in EAE and in vitro. MMP-12 transcripts increased with EAE, and protein was localized to a subset of macrophages/microglia. The temporal expression of MMP-12 largely corres...

Probiotics immunomodulatory properties and their beneficial effects for diseases such as multiple sclerosis (MS) are reported by several studies. The current systematic review meta-analysis aimed to investigate the favourable of probiotics in improving experimental autoimmune/allergic encephalomyelitis (EAE) an animal model MS. We systematically searched Scopus, Web Sciences (ISI), PubMed datab...