Immunoregulation is central for successful manipulation of schistosomiasis. Unlike schistosome vaccine development strategies that relied on direct selection of antigens from crude responses leading to selection of mildly protective antigens, the present study tested the utility of selection of potentially protective antigens encompassed rounds of immunoregulation via idiotypic network. Anti-id...

An exact algebraic expression is derived for the diffusivity of H between interstitial sites in the hexagonal C14 AB2 structure in terms of the jump rates between the sites. The expression is valid in the low concentration limit. The theory is applied to obtaining H jump rates from diffusivity data for ZrCr2Hx.

A luminescence supramolecular hyperbranched polymer is reversibly fabricated by successively adding acid and base to a solution of an AB2 platinum(II) monomer in dichloromethane on the basis of acid-base controllable host-guest recognition of dibenzo[24]crown-8 moieties with dialkylammonium ion centers.

A concise solid-phase synthesis of inverse poly(amidoamine) dendrons was developed. Upon introduction of AB2-type monomers, each dendron generation was constructed via one reaction. G2 to G5 dendrons were constructed in a peptide synthesizer in 93%, 89%, 82%, and 78% yields, respectively, within 5 days.

We generated an IgG1 murine monoclonal anti-idiotype antibody (Ab2) to a highly restricted T-cell antigen designated glycoprotein (gp) 37 that is found on T-cell malignancies but not on normal cells. gp37 is identified by the murine monoclonal antibody SN2 (Ab1) against which the Ab2 was raised. Each of four patients with T-cell lymphoma predominantly confined to the skin received a minimum of ...

We recently proposed that a special category of idiotopes called regulatory idiotopes play an important role in idiotype-driven events in an autologous system (1, 2). Regulatory idiotopes are defined by three criteria: the ability to function as autoimmunogens, the potential to become dominantly expressed because they are recognized by regulatory T cells, and their shared expression by antibodi...

An ultrasensitive portable electrochemical immunosensor for human immunodeficiency virus p24 (HIV p24) antigen detection has been developed, whereby the detection sensitivity was 1000 times higher than that of the ELISA method. Firstly, a novel HRP enzyme-antibody copolymer (EV-p24 Ab2) was synthesized through an EnVision regent (EV, a dextrin amine skeleton anchoring more than 100 molecules of...

By chemically modifying the nucleation burst that generates monodisperse FePt nanocrystals, a mixture of Pt and Fe(x)Pt(1-x) nanoparticles forms during a one-pot reaction that includes a small amount of Cu as a catalyst; size-selective precipitation yields a bi-disperse population of Fe(x)Pt(1-x) nanoparticles, which can assemble into high-quality AB2, AB5, and AB13 superlattice structures.