As cancer progresses, a dynamic microenvironment develops that creates and responds to cellular and biophysical cues. Increased intratumoral pressure and corresponding increases in interstitial flow from the tumor bulk to the healthy stroma is an observational hallmark of progressing cancers. Until recently, the role of interstitial flow was thought to be mostly passive in the transport and dis...

A new algorithm is presented for simulating volume-controlled invasion of a non-wetting phase into voxel images. This method complementary to the traditional morphological image opening which mimics pressure-based invasion. key advantage volume-based approach that fluid configuration at any saturation between 0 and 1 can obtained rather than irregularly widely spaced steps by methods. Because i...

A multi-scale scheme for the invasion percolation of rock fracture networks with heterogeneous fracture aperture fields is proposed. Inside fractures, fluid transport is calculated on the finest scale and found to be localized in channels as a consequence of the aperture field. The channel network is characterized and reduced to a vectorized artificial channel network (ACN). Different realizati...

Many solid tumors exhibit elevated interstitial fluid pressure (IFP). This elevated pressure within the core of the tumor results in outward flow of interstitial fluid to the tumor periphery. We previously found that the directionality of IFP gradients modulates collective invasion from the surface of patterned three-dimensional (3D) aggregates of MDA-MB-231 human breast cancer cells. Here, we ...

The drilling fluid invasion into hydrate-bearing sediments will change the geomechanical properties of reservoir and may lead to uncontrolled geological disasters in worst case. Native are replaced with artificial samples this study investigate effect on strength behaviors sediments. triaxial test is used primarily assess at varying temperatures, pressures, hydrate saturation levels. process wa...

To determine the involvement of human cytomegalovirus (CMV) in conditions of neurological impairment, detection of CMV DNA was attempted in cerebrospinal fluid obtained from 45 neurologically affected children aged from 1 month to 17 years by means of the polymerase chain reaction. Four patients (congenital CMV encephalopathy with West's syndrome, acute encephalitis, chronic epileptic encephalo...

In the process of drilling, drilling fluid will invade into bedding plane shale under action pressure difference that cause hydration collapse and wellbore instability. order to ensure stability during oil gas it is necessary clarify invasion law along fractures process. The immersion experiment method often used study fluid, which quite different from actual underground. this paper, depth conf...

Flow in a porous medium, a problem with important practical applications, has motivated a large number of theoretical and experimental studies [1]. Aiming to understand the complex interplay between the dynamics of flow processes and randomness characterizing the porous medium, a number of models have been introduced that capture different aspects of various experimental situations. One of the ...