Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial cells, and mesenchymal stem cells. A microfluidic cell culture system was designed to apply stable pressure gradients and fluid flow and allow direct visualization of tra...

Rheumatoid arthritis (RA) is characterized by synovial hyperplasia and destruction of cartilage and bone. The fibroblast-like synoviocyte (FLS) population is central to the development of pannus by migrating into cartilage and bone. We demonstrated previously that expression of the cell cycle inhibitor p21 is significantly reduced in RA synovial lining, particularly in the FLS. The aim of this ...

Plate tectonics and volcanism involve the formation, migration, and interaction of magma and gas. Experiments show that melt inclusions subjected to a thermal gradient migrate through olivine crystals, under the kinetic control of crystal-melt interface mechanisms. Exsolved gas bubbles remain fixed and eventually separate from the melt. Scaled to thermal gradients in Earth's mantle and geologic...

Changes in cell size often accompany multicellular motion in tissue, and cell number density is known to strongly influence collective migration in monolayers. Density fluctuations in other forms of active matter have been explored extensively, but not the potential role of density fluctuations in collective cell migration. Here we investigate collective motion in cell monolayers, focusing on t...

The cross-stream migration of a deformable drop in a unidirectional shear flow of a second-order fluid is considered. Expressions for the particle velocity due to the separate effects of deformation and viscoelastic rheology are obtained. The direction and magnitude of migration are calculated for the particular cases of Poiseuille flow and simple shear flow and compared with experimental data.