Amplification of the c-myc gene has been reported in non-small cell lung cancer(NSCLC). We performed dual color fluorescence in situ hybridization(FISH)to detect amplifications of the c-myc gene on chromosome 8 to evaluate the relationship between these possible abnormalities and pathological stage. Tumor tissue samples were obtained from 29 patients of NSCLC in Stage I(n=15)and III(n=14)who un...

Amplification of the c-myc gene has been reported in non-small cell lung cancer (NSCLC). We performed dual color fluorescence in situ hybridization (FISH) to detect amplifications of the c-myc gene on chromosome 8 to evaluate the relationship between these possible abnormalities and pathological stage. Tumor tissue samples were obtained from 29 patients of NSCLC in Stage I (n = 15) and III (n =...

Isolated blastomeres from 8- to 16-cell-stage embryos were fused by standard micromanipulatory means with either unfertilized eggs or fertilized or haploid parthenogenetically activated pronuclear-stage embryos. The hybrid eggs/embryos were incubated overnight in the presence of Colcemid until they had entered the first cleavage division. Air-dried chromosome preparations were then stained with...

BACKGROUND Human herpesvirus 8 (HHV-8), also known as Kaposi's Sarcoma - associated herpesvirus (KSHV) was first identified and detected in 1994 in patients with Kaposi's Sarcoma. Recently, a strong association has been shown between HHV-8 and large-plaque parapsoriasis and mycosis fungoides(MF). This association has been attributed to either recent infection or reactivation of HHV-8 in patient...

average peak perf./ cost average perf/cost Data path cost Performance Performance/Cost peak (1 2 2 2 3 6) (1 2 2 2 3 6) (1 2 2 2 3 6) Stages 6/6 6/5 6/4 6/3 6/2 6/1 6/6 6/5 6/4 6/3 6/2 6/1 6/6 6/5 6/4 6/3 6/2 6/1 Designs (a) (b) (c) Figure 9: Cost/Performance implemented the TDY-43, a 250 instruction processor which supports eight addressing modes. From an ISA speci cation, ADAS produced a gate...

While research supports amyloid-β (Aβ) as the etiologic agent of Alzheimer's disease (AD), the mechanism of action remains unclear. Evidence indicates that adducts of RNA caused by oxidation also represent an early phenomenon in AD. It is currently unknown what type of influence these two observations have on each other, if any. We quantified five RNA adducts by gas chromatography/mass spectros...

In West Africa, Trypanosoma brucei gambiense, causing human African trypanosomiasis (HAT), is associated with a great diversity of infection outcomes. In addition to patients who can be diagnosed in the early hemolymphatic phase (stage 1) or meningoencephalitic phase (stage 2), a number of individuals can mount long-lasting specific serological responses while the results of microscopic investi...

PURPOSE To evaluate factors affecting the use and delay ≥8 weeks of adjuvant chemotherapy and the impact of chemotherapy use and delay on survival. METHODS Between 2005 and 2012, consecutive patients with stage II and III colorectal cancer who were treated with major curative resection were enrolled. RESULTS Among 750 patients with stage II (n = 318) and III (n = 432) disease, 153 (20.4%) d...

BACKGROUND The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This system had limitation because most patients included in the analysis were treated with surgery. Therefore, it might be difficult to reflect prognosis of patients treated with curative concurrent chemoradiotherapy (CCRT). Purpose of this study was to ...