Extended-release matrix tablets of diltiazem hydrochloride (DTZ) were prepared using waxy materials alone or in combination with Kollidon SR. Matrix waxy materials were carnauba wax (CW), bees wax (BW), cetyl alcohol (CA) and glyceryl monostearate (GMS). Dissolution studies were carried out by using a six stations USP XXII type 1 apparatus. The in vitro drug release study was done in 1000 ml ph...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

An approximate analytical solution of transient diffusion equation with space-fractional Riemann–Liouville fractional derivative has been developed. The integral-balance method and an assumed parabolic profile with undefined exponent have been used. The spatial correlation the superdiffusion coefficient in potential power-law form has been discussed. The laws of the spatial and temporal propaga...

extended-release matrix tablets of diltiazem hydrochloride (dtz) were prepared using waxy materials alone or in combination with kollidon sr. matrix waxy materials were carnauba wax (cw), bees wax (bw), cetyl alcohol (ca) and glyceryl monostearate (gms). dissolution studies were carried out by using a six stations usp xxii type 1 apparatus. the in vitro drug release study was done in 1000 ml ph...

Objective The goal of this study was to prepare and characterize alginate microspheres as an antigen delivery system and adjuvant for immunization against leishmaniasis. Materials and Methods Microspheres were prepared by an emulsification technique and characterized for size, encapsulation efficiency, and release profile of encapsulates. Selection of appropriate parameters (viscosity of al...

the present research aims to synthesize the ha/ysz composite and to formulate ha/ysz-gic for improving the fluoride release of the set cement. experiments were performed by mixture design (md) method, and data analysis was carried out by mini- tab 14 software. the results showed that the combination of 25.891wt.% ha, 70.246wt.% zro2 and 3.86wt.% y2o3 has desirable fluoride release profile. comb...

The space-time-fractional diffusion equation with the Caputo time-fractional derivative and Riesz fractional Laplacian is considered in the case of axial symmetry. Mass absorption (mass release) is described by a source term proportional to concentration. The integral transform technique is used. Different particular cases of the solution are studied. The numerical results are illustrated graph...

Abstract Levetiracetam as an Anti-epileptic drug with exclusive mechanism of action is accepted by the USA Food and Drug Administration as an adjunctive therapy in treating epilepsy in young adults. The purpose of this project is the design and formulation of prolonged release of levetiracetam using two types of retarding agent such as Hydroxyl Propyl Methylcellulose (HPMC K4...

The aim of this study is to formulate a novel ophthalmic nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of acyclovir (ACV). In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...